1z6o

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (00:43, 21 November 2024) (edit) (undo)
 
(9 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:1z6o.png|left|200px]]
 
-
<!--
+
==Crystal Structure of Trichoplusia ni secreted ferritin==
-
The line below this paragraph, containing "STRUCTURE_1z6o", creates the "Structure Box" on the page.
+
<StructureSection load='1z6o' size='340' side='right'caption='[[1z6o]], [[Resolution|resolution]] 1.91&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[1z6o]] is a 24 chain structure with sequence from [https://en.wikipedia.org/wiki/Trichoplusia_ni Trichoplusia ni]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z6O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Z6O FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.91&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene></td></tr>
-
{{STRUCTURE_1z6o| PDB=1z6o | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1z6o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z6o OCA], [https://pdbe.org/1z6o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1z6o RCSB], [https://www.ebi.ac.uk/pdbsum/1z6o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1z6o ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/FRIL_TRINI FRIL_TRINI] Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation (By similarity). Ferritin is composed of a heavy (H) chain which is responsible for the oxidation and uptake of ferrous iron, and a light (L) chain which facilitates the nucleation of the ferrihydrite iron core (Probable).[RuleBase:RU361145]<ref>PMID:15896348</ref>
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z6/1z6o_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1z6o ConSurf].
 +
<div style="clear:both"></div>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
Ferritins are iron storage proteins made of 24 subunits forming a hollow spherical shell. Vertebrate ferritins contain varying ratios of heavy (H) and light (L) chains; however, known ferritin structures include only one type of chain and have octahedral symmetry. Here, we report the 1.9A structure of a secreted insect ferritin from Trichoplusia ni, which reveals equal numbers of H and L chains arranged with tetrahedral symmetry. The H/L-chain interface includes complementary features responsible for ordered assembly of the subunits. The H chain contains a ferroxidase active site resembling that of vertebrate H chains with an endogenous, bound iron atom. The L chain lacks the residues that form a putative iron core nucleation site in vertebrate L chains. Instead, a possible nucleation site is observed at the L chain 3-fold pore. The structure also reveals inter- and intrasubunit disulfide bonds, mostly in the extended N-terminal regions unique to insect ferritins. The symmetrical arrangement of H and L chains and the disulfide crosslinks reflect adaptations of insect ferritin to its role as a secreted protein.
-
===Crystal Structure of Trichoplusia ni secreted ferritin===
+
Crystal structure of a secreted insect ferritin reveals a symmetrical arrangement of heavy and light chains.,Hamburger AE, West AP Jr, Hamburger ZA, Hamburger P, Bjorkman PJ J Mol Biol. 2005 Jun 10;349(3):558-69. Epub 2005 Apr 12. PMID:15896348<ref>PMID:15896348</ref>
 +
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 +
</div>
 +
<div class="pdbe-citations 1z6o" style="background-color:#fffaf0;"></div>
-
<!--
+
==See Also==
-
The line below this paragraph, {{ABSTRACT_PUBMED_15896348}}, adds the Publication Abstract to the page
+
*[[Ferritin 3D structures|Ferritin 3D structures]]
-
(as it appears on PubMed at http://www.pubmed.gov), where 15896348 is the PubMed ID number.
+
== References ==
-
-->
+
<references/>
-
{{ABSTRACT_PUBMED_15896348}}
+
__TOC__
-
 
+
</StructureSection>
-
==About this Structure==
+
[[Category: Large Structures]]
-
1Z6O is a 24 chains structure of sequences from [http://en.wikipedia.org/wiki/Trichoplusia_ni Trichoplusia ni]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z6O OCA].
+
-
 
+
-
==Reference==
+
-
<ref group="xtra">PMID:15896348</ref><references group="xtra"/>
+
[[Category: Trichoplusia ni]]
[[Category: Trichoplusia ni]]
-
[[Category: Bjorkman, P J.]]
+
[[Category: Bjorkman PJ]]
-
[[Category: Hamburger, A E.]]
+
[[Category: Hamburger AE]]
-
[[Category: Hamburger, P.]]
+
[[Category: Hamburger P]]
-
[[Category: Hamburger, Z A.]]
+
[[Category: Hamburger ZA]]
-
[[Category: Jr., A P.West.]]
+
[[Category: West Jr AP]]
-
[[Category: Metal binding protein,iron storage]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 04:39:00 2009''
+

Current revision

Crystal Structure of Trichoplusia ni secreted ferritin

PDB ID 1z6o

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1z6o"
Personal tools