2iy3

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{{Seed}}
 
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[[Image:2iy3.png|left|200px]]
 
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==Structure of the E. Coli Signal Regognition Particle==
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The line below this paragraph, containing "STRUCTURE_2iy3", creates the "Structure Box" on the page.
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<SX load='2iy3' size='340' side='right' viewer='molstar' caption='[[2iy3]], [[Resolution|resolution]] 16.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2iy3]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli], [https://en.wikipedia.org/wiki/Saccharolobus_solfataricus Saccharolobus solfataricus], [https://en.wikipedia.org/wiki/Thermus_aquaticus Thermus aquaticus] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IY3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2IY3 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 16&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2iy3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2iy3 OCA], [https://pdbe.org/2iy3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2iy3 RCSB], [https://www.ebi.ac.uk/pdbsum/2iy3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2iy3 ProSAT]</span></td></tr>
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{{STRUCTURE_2iy3| PDB=2iy3 | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SRP54_THEAQ SRP54_THEAQ] Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY (By similarity).[HAMAP-Rule:MF_00306][https://www.uniprot.org/uniprot/SRP54_SACS2 SRP54_SACS2] Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.[HAMAP-Rule:MF_00306]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/iy/2iy3_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2iy3 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The prokaryotic signal recognition particle (SRP) targets membrane proteins into the inner membrane. It binds translating ribosomes and screens the emerging nascent chain for a hydrophobic signal sequence, such as the transmembrane helix of inner membrane proteins. If such a sequence emerges, the SRP binds tightly, allowing the SRP receptor to lock on. This assembly delivers the ribosome-nascent chain complex to the protein translocation machinery in the membrane. Using cryo-electron microscopy and single-particle reconstruction, we obtained a 16 A structure of the Escherichia coli SRP in complex with a translating E. coli ribosome containing a nascent chain with a transmembrane helix anchor. We also obtained structural information on the SRP bound to an empty E. coli ribosome. The latter might share characteristics with a scanning SRP complex, whereas the former represents the next step: the targeting complex ready for receptor binding. High-resolution structures of the bacterial ribosome and of the bacterial SRP components are available, and their fitting explains our electron microscopic density. The structures reveal the regions that are involved in complex formation, provide insight into the conformation of the SRP on the ribosome and indicate the conformational changes that accompany high-affinity SRP binding to ribosome nascent chain complexes upon recognition of the signal sequence.
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===STRUCTURE OF THE E. COLI SIGNAL RECOGNITION PARTICLE BOUND TO A TRANSLATING RIBOSOME===
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Structure of the E. coli signal recognition particle bound to a translating ribosome.,Schaffitzel C, Oswald M, Berger I, Ishikawa T, Abrahams JP, Koerten HK, Koning RI, Ban N Nature. 2006 Nov 23;444(7118):503-6. Epub 2006 Oct 29. PMID:17086205<ref>PMID:17086205</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2iy3" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_17086205}}, adds the Publication Abstract to the page
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*[[Signal recognition particle 3D structures|Signal recognition particle 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 17086205 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_17086205}}
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__TOC__
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</SX>
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==About this Structure==
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[[Category: Escherichia coli]]
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2IY3 is a 3 chains structure of sequences from [http://en.wikipedia.org/wiki/Thermus_aquaticus Thermus aquaticus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IY3 OCA].
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[[Category: Large Structures]]
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[[Category: Saccharolobus solfataricus]]
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==Reference==
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[[Category: Synthetic construct]]
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<ref group="xtra">PMID:17086205</ref><references group="xtra"/>
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[[Category: Thermus aquaticus]]
[[Category: Thermus aquaticus]]
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[[Category: Abrahams, J P.]]
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[[Category: Abrahams JP]]
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[[Category: Ban, N.]]
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[[Category: Ban N]]
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[[Category: Berger, I.]]
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[[Category: Berger I]]
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[[Category: Ishikawa, T.]]
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[[Category: Ishikawa T]]
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[[Category: Koerten, H K.]]
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[[Category: Koerten HK]]
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[[Category: Koning, R I.]]
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[[Category: Koning RI]]
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[[Category: Oswald, M.]]
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[[Category: Oswald M]]
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[[Category: Schaffitzel, C.]]
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[[Category: Schaffitzel C]]
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[[Category: Rna-binding protein complex]]
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[[Category: Signal recognition particle]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 04:46:33 2009''
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Current revision

Structure of the E. Coli Signal Regognition Particle

2iy3, resolution 16.00Å

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