2zbs

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{{Seed}}
 
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[[Image:2zbs.png|left|200px]]
 
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==Crystal structure of human estrogen-related receptor gamma ligand binding domain apo form==
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The line below this paragraph, containing "STRUCTURE_2zbs", creates the "Structure Box" on the page.
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<StructureSection load='2zbs' size='340' side='right'caption='[[2zbs]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2zbs]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZBS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ZBS FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2zbs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zbs OCA], [https://pdbe.org/2zbs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2zbs RCSB], [https://www.ebi.ac.uk/pdbsum/2zbs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2zbs ProSAT]</span></td></tr>
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{{STRUCTURE_2zbs| PDB=2zbs | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ERR3_HUMAN ERR3_HUMAN] Orphan receptor that acts as transcription activator in the absence of bound ligand. Binds specifically to an estrogen response element and activates reporter genes controlled by estrogen response elements (By similarity).<ref>PMID:19067653</ref> <ref>PMID:18063693</ref> <ref>PMID:11864604</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zb/2zbs_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2zbs ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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A receptor-binding assay and X-ray crystal structure analysis demonstrated that the endocrine disruptor bisphenol A (BPA) strongly binds to human estrogen-related receptor gamma (ERRgamma). BPA is well anchored to the ligand-binding pocket, forming hydrogen bonds with its two phenol-hydroxyl groups. In this study, we found that 4-alpha-cumylphenol lacking one of its phenol-hydroxyl groups also binds to ERRgamma very strongly. The 2.0 A crystal structure of the 4-alpha-cumylphenol/ERRgamma complex clearly revealed that ERRgamma's Leu345-beta-isopropyl plays a role in the tight binding of 4-alpha-cumylphenol and BPA, rotating in a back-and-forth induced-fit manner.
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===Crystal structure of human estrogen-related receptor gamma ligand binding domain apo form===
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ERRgamma tethers strongly bisphenol A and 4-alpha-cumylphenol in an induced-fit manner.,Matsushima A, Teramoto T, Okada H, Liu X, Tokunaga T, Kakuta Y, Shimohigashi Y Biochem Biophys Res Commun. 2008 Aug 29;373(3):408-13. Epub 2008 Jun 26. PMID:18582436<ref>PMID:18582436</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2zbs" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_18582436}}, adds the Publication Abstract to the page
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*[[Estrogen-related receptor 3D structures|Estrogen-related receptor 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 18582436 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_18582436}}
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__TOC__
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</StructureSection>
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==About this Structure==
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2ZBS is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZBS OCA].
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==Reference==
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<ref group="xtra">PMID:18582436</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Kakuta, Y.]]
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[[Category: Large Structures]]
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[[Category: Matsushima, A.]]
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[[Category: Kakuta Y]]
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[[Category: Shimohigashi, Y.]]
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[[Category: Matsushima A]]
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[[Category: Teramoto, T.]]
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[[Category: Shimohigashi Y]]
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[[Category: Activator]]
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[[Category: Teramoto T]]
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[[Category: Alternative splicing]]
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[[Category: Apo form]]
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[[Category: Dna-binding]]
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[[Category: Err gamma]]
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[[Category: Metal-binding]]
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[[Category: Nuclear receptor]]
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[[Category: Nucleus]]
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[[Category: Polymorphism]]
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[[Category: Transcription]]
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[[Category: Transcription regulation]]
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[[Category: Zinc]]
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[[Category: Zinc-finger]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 04:51:06 2009''
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Current revision

Crystal structure of human estrogen-related receptor gamma ligand binding domain apo form

PDB ID 2zbs

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