3coi

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{{Seed}}
 
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[[Image:3coi.png|left|200px]]
 
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==Crystal structure of p38delta kinase==
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The line below this paragraph, containing "STRUCTURE_3coi", creates the "Structure Box" on the page.
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<StructureSection load='3coi' size='340' side='right'caption='[[3coi]], [[Resolution|resolution]] 2.09&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3coi]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3COI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3COI FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.09&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3coi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3coi OCA], [https://pdbe.org/3coi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3coi RCSB], [https://www.ebi.ac.uk/pdbsum/3coi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3coi ProSAT], [https://www.topsan.org/Proteins/NYSGXRC/3coi TOPSAN]</span></td></tr>
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{{STRUCTURE_3coi| PDB=3coi | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MK13_HUMAN MK13_HUMAN] Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK13 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. MAPK13 is one of the less studied p38 MAPK isoforms. Some of the targets are downstream kinases such as MAPKAPK2, which are activated through phosphorylation and further phosphorylate additional targets. Plays a role in the regulation of protein translation by phosphorylating and inactivating EEF2K. Involved in cytoskeletal remodeling through phosphorylation of MAPT and STMN1. Mediates UV irradiation induced up-regulation of the gene expression of CXCL14. Plays an important role in the regulation of epidermal keratinocyte differentiation, apoptosis and skin tumor development. Phosphorylates the transcriptional activator MYB in response to stress which leads to rapid MYB degradation via a proteasome-dependent pathway. MAPK13 also phosphorylates and down-regulates PRKD1 during regulation of insulin secretion in pancreatic beta cells.<ref>PMID:9731215</ref> <ref>PMID:11500363</ref> <ref>PMID:11943212</ref> <ref>PMID:15632108</ref> <ref>PMID:17256148</ref> <ref>PMID:18006338</ref> <ref>PMID:18367666</ref> <ref>PMID:20478268</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/co/3coi_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3coi ConSurf].
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<div style="clear:both"></div>
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===Crystal structure of p38delta kinase===
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==See Also==
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*[[Mitogen-activated protein kinase 3D structures|Mitogen-activated protein kinase 3D structures]]
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== References ==
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==About this Structure==
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<references/>
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3COI is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3COI OCA].
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Mitogen-activated protein kinase]]
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[[Category: Large Structures]]
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[[Category: Atwell, S.]]
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[[Category: Atwell S]]
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[[Category: Burley, S K.]]
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[[Category: Burley SK]]
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[[Category: Houle, A.]]
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[[Category: Houle A]]
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[[Category: NYSGXRC, New York SGX Research Center for Structural Genomics.]]
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[[Category: Ramos A]]
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[[Category: Ramos, A.]]
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[[Category: Sauder JM]]
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[[Category: Sauder, J M.]]
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[[Category: Atp-binding]]
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[[Category: Cell cycle]]
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[[Category: Erk]]
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[[Category: Kinase]]
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[[Category: Map kinase]]
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[[Category: New york sgx research center for structural genomic]]
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[[Category: Nucleotide-binding]]
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[[Category: Nysgxrc]]
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[[Category: P38-2]]
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[[Category: P38d]]
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[[Category: P38delta]]
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[[Category: Phosphoprotein]]
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[[Category: Pmk]]
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[[Category: Protein structure initiative]]
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[[Category: Psi]]
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[[Category: Serine/threonine-protein kinase]]
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[[Category: Stk26]]
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[[Category: Stress-activated protein kinase]]
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[[Category: Structural genomic]]
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[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 05:03:33 2009''
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Current revision

Crystal structure of p38delta kinase

PDB ID 3coi

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