1gh2

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{{Seed}}
 
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[[Image:1gh2.png|left|200px]]
 
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==Crystal structure of the catalytic domain of a new human thioredoxin-like protein==
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The line below this paragraph, containing "STRUCTURE_1gh2", creates the "Structure Box" on the page.
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<StructureSection load='1gh2' size='340' side='right'caption='[[1gh2]], [[Resolution|resolution]] 2.22&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1gh2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GH2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1GH2 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.22&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1gh2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gh2 OCA], [https://pdbe.org/1gh2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1gh2 RCSB], [https://www.ebi.ac.uk/pdbsum/1gh2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1gh2 ProSAT]</span></td></tr>
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{{STRUCTURE_1gh2| PDB=1gh2 | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TXNL1_HUMAN TXNL1_HUMAN] Active thioredoxin with a redox potential of about -250 mV.<ref>PMID:19349277</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gh/1gh2_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1gh2 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Thioredoxin is a ubiquitous dithiol oxidoreductase found in many organisms and involved in numerous biochemical processes. Human thioredoxin-like protein (hTRXL) is differentially expressed at different development stages of human fetal cerebrum and belongs to an expanding family of thioredoxins. We have solved the crystal structure of the recombinant N-terminal catalytic domain (hTRXL-N) of hTRXL in its oxidized form at 2.2-A resolution. Although this domain shares a similar three-dimensional structure with human thioredoxin (hTRX), a unique feature of hTRXL-N is the large number of positively charged residues distributed around the active site, which has been implicated in substrate specificity. Furthermore, the hTRXL-N crystal structure is monomeric while hTRX is dimeric in its four crystal structures (reduced, oxidized, C73S and C32S/C35S mutants) reported to date. As dimerization is the key regulatory factor in hTRX, the positive charge and lack of dimer formation of hTRXL-N suggest that it could interact with the acidic amino-acid rich C-terminal region, thereby suggesting a novel regulation mechanism.
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===Crystal structure of the catalytic domain of a new human thioredoxin-like protein===
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Crystal structure of the catalytic domain of a human thioredoxin-like protein.,Jin J, Chen X, Zhou Y, Bartlam M, Guo Q, Liu Y, Sun Y, Gao Y, Ye S, Li G, Rao Z, Qiang B, Yuan J Eur J Biochem. 2002 Apr;269(8):2060-8. PMID:11985582<ref>PMID:11985582</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_11985582}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1gh2" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 11985582 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_11985582}}
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__TOC__
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</StructureSection>
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==About this Structure==
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1GH2 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GH2 OCA].
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==Reference==
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<ref group="xtra">PMID:11985582</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Chen, X.]]
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[[Category: Large Structures]]
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[[Category: Guo, Q.]]
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[[Category: Chen X]]
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[[Category: Jin, J.]]
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[[Category: Guo Q]]
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[[Category: Qiang, B.]]
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[[Category: Jin J]]
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[[Category: Rao, Z.]]
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[[Category: Qiang B]]
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[[Category: Yuan, J.]]
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[[Category: Rao Z]]
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[[Category: Redox-active center]]
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[[Category: Yuan J]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 05:10:48 2009''
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Current revision

Crystal structure of the catalytic domain of a new human thioredoxin-like protein

PDB ID 1gh2

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