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2o1u

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{{Seed}}
 
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[[Image:2o1u.png|left|200px]]
 
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==Structure of full length GRP94 with AMP-PNP bound==
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The line below this paragraph, containing "STRUCTURE_2o1u", creates the "Structure Box" on the page.
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<StructureSection load='2o1u' size='340' side='right'caption='[[2o1u]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2o1u]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Canis_lupus_familiaris Canis lupus familiaris]. The December 2008 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Hsp90'' by David Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2008_12 10.2210/rcsb_pdb/mom_2008_12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O1U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2O1U FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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{{STRUCTURE_2o1u| PDB=2o1u | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2o1u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2o1u OCA], [https://pdbe.org/2o1u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2o1u RCSB], [https://www.ebi.ac.uk/pdbsum/2o1u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2o1u ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ENPL_CANLF ENPL_CANLF] Molecular chaperone that functions in the processing and transport of secreted proteins. When associated with CNPY3, required for proper folding of Toll-like receptors. Functions in endoplasmic reticulum associated degradation (ERAD). Has ATPase activity (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/o1/2o1u_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2o1u ConSurf].
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<div style="clear:both"></div>
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===Structure of full length GRP94 with AMP-PNP bound===
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==See Also==
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*[[Heat Shock Protein structures|Heat Shock Protein structures]]
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__TOC__
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</StructureSection>
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(as it appears on PubMed at http://www.pubmed.gov), where 17936703 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17936703}}
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==About this Structure==
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2O1U is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Canis_lupus_familiaris Canis lupus familiaris]. The December 2008 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Hsp90'' by David Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2008_12 10.2210/rcsb_pdb/mom_2008_12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O1U OCA].
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==Reference==
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<ref group="xtra">PMID:17936703</ref><references group="xtra"/>
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[[Category: Canis lupus familiaris]]
[[Category: Canis lupus familiaris]]
[[Category: Hsp90]]
[[Category: Hsp90]]
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[[Category: Dollins, D E.]]
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[[Category: Large Structures]]
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[[Category: Gewirth, D T.]]
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[[Category: RCSB PDB Molecule of the Month]]
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[[Category: Immormino, R M.]]
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[[Category: Dollins DE]]
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[[Category: Warren, J J.]]
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[[Category: Gewirth DT]]
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[[Category: Amp-pnp]]
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[[Category: Immormino RM]]
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[[Category: Chaperone]]
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[[Category: Warren JJ]]
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[[Category: Endoplasmin]]
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[[Category: Gp96]]
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[[Category: Grp94]]
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[[Category: Hsp82]]
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[[Category: Hsp90]]
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[[Category: Htpg]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 05:15:30 2009''
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Current revision

Structure of full length GRP94 with AMP-PNP bound

PDB ID 2o1u

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