1wm4

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{{Seed}}
 
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[[Image:1wm4.png|left|200px]]
 
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==Solution structure of mouse coactosin, an actin filament binding protein==
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The line below this paragraph, containing "STRUCTURE_1wm4", creates the "Structure Box" on the page.
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<StructureSection load='1wm4' size='340' side='right'caption='[[1wm4]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1wm4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WM4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WM4 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wm4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wm4 OCA], [https://pdbe.org/1wm4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wm4 RCSB], [https://www.ebi.ac.uk/pdbsum/1wm4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wm4 ProSAT]</span></td></tr>
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{{STRUCTURE_1wm4| PDB=1wm4 | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/COTL1_MOUSE COTL1_MOUSE] Binds to F-actin in a calcium-independent manner. Has no direct effect on actin depolymerization.<ref>PMID:11785969</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wm/1wm4_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1wm4 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Coactosin is a small (MW approximately 15 kDa) evolutionarily conserved actin filament binding protein. It displays remote sequence homology to ADF/cofilin proteins and to the ADF-H domains of twinfilin and Abp1/drebrin. However, biochemical analyses have demonstrated that coactosin has a very different role in actin dynamics from the ones of ADF/cofilin, twinfilin or Abp1/drebrin. To elucidate the molecular mechanism of coactosin/actin interaction, we determined the three-dimensional structure of mouse coactosin by multidimensional NMR spectroscopy. We find that the coactosin structure is homologous to ADF/cofilin and to the ADF-H domains of twinfilin. Furthermore, the regions that have been shown to be important for actin filament interactions in ADF/cofilins are structurally conserved in coactosin suggesting that these two proteins interact with F-actin through a conserved interface. Our analysis also identifies key structural differences between these proteins that may account for the differences in biochemical activities and cellular roles of these proteins.
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===Solution structure of mouse coactosin, an actin filament binding protein===
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Solution structure of coactosin reveals structural homology to ADF/cofilin family proteins.,Hellman M, Paavilainen VO, Naumanen P, Lappalainen P, Annila A, Permi P FEBS Lett. 2004 Oct 8;576(1-2):91-6. PMID:15474017<ref>PMID:15474017</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_15474017}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1wm4" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 15474017 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_15474017}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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1WM4 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WM4 OCA].
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==Reference==
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<ref group="xtra">PMID:15474017</ref><references group="xtra"/>
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[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Annila, A.]]
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[[Category: Annila A]]
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[[Category: Hellman, M.]]
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[[Category: Hellman M]]
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[[Category: Lappalainen, P.]]
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[[Category: Lappalainen P]]
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[[Category: Naumanen, P.]]
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[[Category: Naumanen P]]
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[[Category: Paavilainen, V O.]]
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[[Category: Paavilainen VO]]
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[[Category: Permi, P.]]
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[[Category: Permi P]]
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[[Category: Adf-h domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 05:15:39 2009''
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Current revision

Solution structure of mouse coactosin, an actin filament binding protein

PDB ID 1wm4

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