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2p82

From Proteopedia

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{{Seed}}
 
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[[Image:2p82.png|left|200px]]
 
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==Cysteine protease ATG4A==
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The line below this paragraph, containing "STRUCTURE_2p82", creates the "Structure Box" on the page.
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<StructureSection load='2p82' size='340' side='right'caption='[[2p82]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2p82]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P82 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2P82 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
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{{STRUCTURE_2p82| PDB=2p82 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2p82 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2p82 OCA], [https://pdbe.org/2p82 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2p82 RCSB], [https://www.ebi.ac.uk/pdbsum/2p82 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2p82 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ATG4A_HUMAN ATG4A_HUMAN] Cysteine protease required for autophagy, which cleaves the C-terminal part of either MAP1LC3, GABARAPL2 or GABARAP, allowing the liberation of form I. A subpopulation of form I is subsequently converted to a smaller form (form II). Form II, with a revealed C-terminal glycine, is considered to be the phosphatidylethanolamine (PE)-conjugated form, and has the capacity for the binding to autophagosomes. Preferred substrate is GABARAPL2 followed by MAP1LC3A and GABARAP.<ref>PMID:15169837</ref> <ref>PMID:12473658</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/p8/2p82_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2p82 ConSurf].
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<div style="clear:both"></div>
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===Cysteine protease ATG4A===
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==See Also==
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*[[Autophagy-related protein 3D structures|Autophagy-related protein 3D structures]]
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== References ==
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==About this Structure==
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<references/>
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2P82 is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P82 OCA].
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__TOC__
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</StructureSection>
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==Reference==
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<ref group="xtra">PMID:12446702</ref><ref group="xtra">PMID:15169837</ref><ref group="xtra">PMID:12473658</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Arrowsmith, C H.]]
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[[Category: Large Structures]]
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[[Category: Bochkarev, A.]]
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[[Category: Arrowsmith CH]]
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[[Category: Butler-Cole, C.]]
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[[Category: Bochkarev A]]
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[[Category: Davis, T.]]
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[[Category: Butler-Cole C]]
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[[Category: Dhe-Paganon, S.]]
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[[Category: Davis T]]
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[[Category: Edwards, A M.]]
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[[Category: Dhe-Paganon S]]
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[[Category: Jr., P J.Finerty.]]
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[[Category: Edwards AM]]
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[[Category: Mujib, S.]]
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[[Category: Finerty Jr PJ]]
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[[Category: SGC, Structural Genomics Consortium.]]
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[[Category: Mujib S]]
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[[Category: Sundstrom, M.]]
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[[Category: Sundstrom M]]
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[[Category: Walker, J R.]]
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[[Category: Walker JR]]
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[[Category: Weigelt, J.]]
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[[Category: Weigelt J]]
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[[Category: Autophagy]]
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[[Category: Hydrolase]]
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[[Category: Protease]]
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[[Category: Protein transport]]
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[[Category: Sgc]]
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[[Category: Structural genomic]]
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[[Category: Structural genomics consortium]]
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[[Category: Thiol protease]]
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[[Category: Transport]]
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[[Category: Ubl conjugation pathway]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 05:28:26 2009''
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Current revision

Cysteine protease ATG4A

PDB ID 2p82

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