1t1u

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (06:23, 23 August 2023) (edit) (undo)
 
(9 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:1t1u.png|left|200px]]
 
-
<!--
+
==Structural Insights and Functional Implications of Choline Acetyltransferase==
-
The line below this paragraph, containing "STRUCTURE_1t1u", creates the "Structure Box" on the page.
+
<StructureSection load='1t1u' size='340' side='right'caption='[[1t1u]], [[Resolution|resolution]] 1.55&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[1t1u]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T1U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1T1U FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.55&#8491;</td></tr>
-
-->
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1t1u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t1u OCA], [https://pdbe.org/1t1u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1t1u RCSB], [https://www.ebi.ac.uk/pdbsum/1t1u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1t1u ProSAT]</span></td></tr>
-
{{STRUCTURE_1t1u| PDB=1t1u | SCENE= }}
+
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/CLAT_RAT CLAT_RAT] Catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses.
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/t1/1t1u_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1t1u ConSurf].
 +
<div style="clear:both"></div>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
The biosynthetic enzyme for the neurotransmitter acetylcholine, choline acetyltransferase (ChAT) (E.C. 2.3.1.6), is essential for the development and neuronal activities of cholinergic systems involved in many fundamental brain functions. ChAT catalyzes the transfer of an acetyl group from acetyl-coenzyme A to choline to form the neurotransmitter acetylcholine. Since its discovery more than 60 years ago much research has been devoted to the kinetic studies of this enzyme. For the first time we report the crystal structure of rat ChAT (rChAT) to 1.55 A resolution. The structure of rChAT is a monomer and consists of two domains with an interfacial active site tunnel. This structure, with the modeled substrate binding, provides critical insights into the molecular basis for the production of acetylcholine and may further our understanding of disease causing mutations.
-
===Structural Insights and Functional Implications of Choline Acetyltransferase===
+
Structural insights and functional implications of choline acetyltransferase.,Govindasamy L, Pedersen B, Lian W, Kukar T, Gu Y, Jin S, Agbandje-McKenna M, Wu D, McKenna R J Struct Biol. 2004 Nov;148(2):226-35. PMID:15477102<ref>PMID:15477102</ref>
 +
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 +
</div>
 +
<div class="pdbe-citations 1t1u" style="background-color:#fffaf0;"></div>
-
<!--
+
==See Also==
-
The line below this paragraph, {{ABSTRACT_PUBMED_15477102}}, adds the Publication Abstract to the page
+
*[[Choline O-acetyltransferase|Choline O-acetyltransferase]]
-
(as it appears on PubMed at http://www.pubmed.gov), where 15477102 is the PubMed ID number.
+
== References ==
-
-->
+
<references/>
-
{{ABSTRACT_PUBMED_15477102}}
+
__TOC__
-
 
+
</StructureSection>
-
==About this Structure==
+
[[Category: Large Structures]]
-
1T1U is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T1U OCA].
+
-
 
+
-
==Reference==
+
-
<ref group="xtra">PMID:15477102</ref><references group="xtra"/>
+
-
[[Category: Choline O-acetyltransferase]]
+
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
-
[[Category: Agbandje-McKenna, M.]]
+
[[Category: Agbandje-McKenna M]]
-
[[Category: Govindasamy, L.]]
+
[[Category: Govindasamy L]]
-
[[Category: Gu, Y.]]
+
[[Category: Gu Y]]
-
[[Category: Jin, S.]]
+
[[Category: Jin S]]
-
[[Category: Kukar, T.]]
+
[[Category: Kukar T]]
-
[[Category: Lian, W.]]
+
[[Category: Lian W]]
-
[[Category: Pedersen, B.]]
+
[[Category: Pedersen B]]
-
[[Category: Wu, D.]]
+
[[Category: Wu D]]
-
[[Category: Choline acetyltransferase]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 05:35:07 2009''
+

Current revision

Structural Insights and Functional Implications of Choline Acetyltransferase

PDB ID 1t1u

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1t1u"
Personal tools