1gio

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{{Seed}}
 
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[[Image:1gio.png|left|200px]]
 
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==NMR SOLUTION STRUCTURE OF BOVINE ANGIOGENIN, 10 STRUCTURES==
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The line below this paragraph, containing "STRUCTURE_1gio", creates the "Structure Box" on the page.
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<StructureSection load='1gio' size='340' side='right'caption='[[1gio]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1gio]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GIO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1GIO FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 10 models</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1gio FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gio OCA], [https://pdbe.org/1gio PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1gio RCSB], [https://www.ebi.ac.uk/pdbsum/1gio PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1gio ProSAT]</span></td></tr>
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{{STRUCTURE_1gio| PDB=1gio | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ANG1_BOVIN ANG1_BOVIN] May function as a tRNA-specific ribonuclease that abolishes protein synthesis by specifically hydrolyzing cellular tRNAs. Binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus. Angiogenin induces vascularization of normal and malignant tissues. Angiogenic activity is regulated by interaction with RNH1 in vivo. Has very low ribonuclease activity.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gi/1gio_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1gio ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The three-dimensional structure of bovine angiogenin has been determined using two- and three-dimensional proton NMR spectroscopy. The solution structure is very close to that recently determined by X-ray diffraction analysis. This structure appears well defined, even if five loops and one helix exhibit greater flexibility. Analysis of the active site geometry confirms the position of the Glu-118 residue which obstructs the pyrimidine binding site. There is no experimental evidence of an unobstructed conformation of angiogenin in solution. In addition, it appears that the Glu-118 and Ser-119 residues and the cell receptor binding loop may play an important role in the differences of C-terminal fragment organization and ribonucleolytic activity observed between angiogenins and ribonuclease A.
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===NMR SOLUTION STRUCTURE OF BOVINE ANGIOGENIN, 10 STRUCTURES===
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Solution structure of bovine angiogenin by 1H nuclear magnetic resonance spectroscopy.,Lequin O, Albaret C, Bontems F, Spik G, Lallemand JY Biochemistry. 1996 Jul 9;35(27):8870-80. PMID:8688423<ref>PMID:8688423</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 1gio" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_8688423}}, adds the Publication Abstract to the page
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*[[Ribonuclease 3D structures|Ribonuclease 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 8688423 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_8688423}}
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__TOC__
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</StructureSection>
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==About this Structure==
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1GIO is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GIO OCA].
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==Reference==
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<ref group="xtra">PMID:8688423</ref><references group="xtra"/>
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[[Category: Bos taurus]]
[[Category: Bos taurus]]
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[[Category: Albaret, C.]]
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[[Category: Large Structures]]
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[[Category: Bontems, F.]]
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[[Category: Albaret C]]
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[[Category: Lallemand, J Y.]]
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[[Category: Bontems F]]
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[[Category: Lequin, O.]]
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[[Category: Lallemand JY]]
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[[Category: Spik, G.]]
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[[Category: Lequin O]]
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[[Category: Endoribonuclease]]
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[[Category: Spik G]]
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[[Category: Hydrolase angiogenesis]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 05:35:08 2009''
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Current revision

NMR SOLUTION STRUCTURE OF BOVINE ANGIOGENIN, 10 STRUCTURES

PDB ID 1gio

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