1sva

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{{Seed}}
 
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[[Image:1sva.png|left|200px]]
 
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==SIMIAN VIRUS 40==
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The line below this paragraph, containing "STRUCTURE_1sva", creates the "Structure Box" on the page.
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<SX load='1sva' size='340' side='right' viewer='molstar' caption='[[1sva]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1sva]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Macaca_mulatta_polyomavirus_1 Macaca mulatta polyomavirus 1]. The November 2003 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Simian Virus 40'' by David S. Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2003_11 10.2210/rcsb_pdb/mom_2003_11]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SVA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SVA FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.1&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1sva FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sva OCA], [https://pdbe.org/1sva PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1sva RCSB], [https://www.ebi.ac.uk/pdbsum/1sva PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1sva ProSAT]</span></td></tr>
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{{STRUCTURE_1sva| PDB=1sva | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/VP1_SV40 VP1_SV40] Forms an icosahedral capsid with a T=7 symmetry and a 40 nm diameter. The capsid is composed of 72 pentamers linked to each other by disulfide bonds and associated with VP2 or VP3 proteins. Binds to N-glycolylneuraminic analog of the ganglioside GM1 on the cell surface to provide virion attachment to target cell. Once attached, the virion is internalized by caveolin-mediated endocytosis and traffics to the endoplasmic reticulum. Inside the endoplasmic reticulum, the protein folding machinery isomerizes VP1 interpentamer disulfide bonds, thereby triggering initial uncoating. Next, the virion uses the endoplasmic reticulum-associated degradation machinery to probably translocate in the cytosol before reaching the nucleus. Nuclear entry of the viral DNA involves the selective exposure and importin recognition of VP2/Vp3 nuclear localization signal. The assembly takes place in the cell nucleus. Encapsulates the genomic DNA and participates in rearranging nucleosomes around the viral DNA. The viral progenies exit the cells by lytic release.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/sv/1sva_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1sva ConSurf].
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<div style="clear:both"></div>
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===SIMIAN VIRUS 40===
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==See Also==
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*[[Art:Pentagonal Garden|Art:Pentagonal Garden]]
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*[[Virus coat proteins 3D structures|Virus coat proteins 3D structures]]
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__TOC__
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</SX>
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(as it appears on PubMed at http://www.pubmed.gov), where 8805523 is the PubMed ID number.
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[[Category: Large Structures]]
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[[Category: Macaca mulatta polyomavirus 1]]
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{{ABSTRACT_PUBMED_8805523}}
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[[Category: RCSB PDB Molecule of the Month]]
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==About this Structure==
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1SVA is a 6 chains structure of sequences from [http://en.wikipedia.org/wiki/Simian_virus_40 Simian virus 40]. The November 2003 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Simian Virus 40'' by David S. Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2003_11 10.2210/rcsb_pdb/mom_2003_11]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SVA OCA].
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==Reference==
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<ref group="xtra">PMID:8805523</ref><references group="xtra"/>
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[[Category: Simian Virus 40]]
[[Category: Simian Virus 40]]
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[[Category: Simian virus 40]]
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[[Category: Gamblin SJ]]
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[[Category: Gamblin, S J.]]
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[[Category: Harrison SC]]
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[[Category: Harrison, S C.]]
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[[Category: Stehle T]]
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[[Category: Stehle, T.]]
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[[Category: Icosahedral virus]]
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[[Category: Virus coat protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 05:38:39 2009''
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Current revision

SIMIAN VIRUS 40

1sva, resolution 3.10Å

Proteopedia Page Contributors and Editors (what is this?)

OCA

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