2q9t

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{{Seed}}
 
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[[Image:2q9t.png|left|200px]]
 
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==High-resolution structure of the DING protein from Pseudomonas fluorescens==
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The line below this paragraph, containing "STRUCTURE_2q9t", creates the "Structure Box" on the page.
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<StructureSection load='2q9t' size='340' side='right'caption='[[2q9t]], [[Resolution|resolution]] 1.43&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2q9t]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_fluorescens_SBW25 Pseudomonas fluorescens SBW25]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q9T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Q9T FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.43&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_2q9t| PDB=2q9t | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2q9t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2q9t OCA], [https://pdbe.org/2q9t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2q9t RCSB], [https://www.ebi.ac.uk/pdbsum/2q9t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2q9t ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/D0VWY2_PSEFS D0VWY2_PSEFS]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/q9/2q9t_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2q9t ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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A recombinant DING protein from Pseudomonas fluorescens has been previously shown to have a phosphate-binding site, and to be mitogenic for human cells. Here we report the three-dimensional structure of the protein, confirming a close similarity to the "Venus flytrap" structure seen in other human and bacterial phosphate-binding proteins. Site-directed mutagenesis confirms the role of a key residue involved in phosphate binding, and that the mitogenic activity is not dependent on this property. Deletion of one of the two hinged domains that constitute the Venus flytrap also eliminates phosphate binding whilst enhancing mitogenic activity.
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===High-resolution structure of the DING protein from Pseudomonas fluorescens===
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Structure-function relationships in a bacterial DING protein.,Ahn S, Moniot S, Elias M, Chabriere E, Kim D, Scott K FEBS Lett. 2007 Jul 24;581(18):3455-60. Epub 2007 Jun 27. PMID:17612529<ref>PMID:17612529</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_17612529}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 2q9t" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 17612529 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_17612529}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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2Q9T is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Pseudomonas_fluorescens Pseudomonas fluorescens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q9T OCA].
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[[Category: Pseudomonas fluorescens SBW25]]
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[[Category: Ahn S]]
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==Reference==
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[[Category: Chabriere E]]
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<ref group="xtra">PMID:17612529</ref><references group="xtra"/>
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[[Category: Elias M]]
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[[Category: Pseudomonas fluorescens]]
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[[Category: Kim D]]
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[[Category: Ahn, S.]]
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[[Category: Moniot S]]
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[[Category: Chabriere, E.]]
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[[Category: Scott K]]
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[[Category: Elias, M.]]
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[[Category: Kim, D.]]
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[[Category: Moniot, S.]]
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[[Category: Scott, K.]]
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[[Category: Ding protein]]
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[[Category: Phosphate-binding]]
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[[Category: Psts protein]]
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[[Category: Unknown function]]
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[[Category: Venus flytrap fold]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 05:50:56 2009''
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Current revision

High-resolution structure of the DING protein from Pseudomonas fluorescens

PDB ID 2q9t

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