1l9v

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{{Seed}}
 
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[[Image:1l9v.png|left|200px]]
 
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==Non Structural protein encoded by gene segment 8 of rotavirus (NSP2), an NTPase, ssRNA binding and nucleic acid helix-destabilizing protein==
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The line below this paragraph, containing "STRUCTURE_1l9v", creates the "Structure Box" on the page.
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<StructureSection load='1l9v' size='340' side='right'caption='[[1l9v]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1l9v]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Simian_11_rotavirus_(serotype_3_/_strain_SA11-Ramig) Simian 11 rotavirus (serotype 3 / strain SA11-Ramig)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L9V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1L9V FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1l9v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l9v OCA], [https://pdbe.org/1l9v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1l9v RCSB], [https://www.ebi.ac.uk/pdbsum/1l9v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1l9v ProSAT]</span></td></tr>
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{{STRUCTURE_1l9v| PDB=1l9v | SCENE= }}
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</table>
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== Function ==
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===Non Structural protein encoded by gene segment 8 of rotavirus (NSP2), an NTPase, ssRNA binding and nucleic acid helix-destabilizing protein===
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[https://www.uniprot.org/uniprot/NSP2_ROTSR NSP2_ROTSR] Involved in genome replication and packaging. Plays a crucial role, together with NSP5, in the formation of virus factories (viroplasms) which are large inclusions in the cytoplasm where replication intermediates are assembled and RNA replication takes place. Displays ssRNA binding, NTPase, RNA triphosphatase (RTPase) and ATP-independent helix-unwinding activity activities. The unwiding activity may prepare and organize plus-strand RNAs for packaging and replication by removing interfering secondary structures. Unlike typical helicases, NSP2 requires neither a divalent cation nor a nucleotide energy source for helix destabilization. The RTPase activity may account for the absence of the 5'-terminal gamma-phosphate on the minus-strands of dsRNA genome segments (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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(as it appears on PubMed at http://www.pubmed.gov), where 12015608 is the PubMed ID number.
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/l9/1l9v_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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{{ABSTRACT_PUBMED_12015608}}
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==About this Structure==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1l9v ConSurf].
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1L9V is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Simian_11_rotavirus_a Simian 11 rotavirus a]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L9V OCA].
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<div style="clear:both"></div>
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:12015608</ref><references group="xtra"/>
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[[Category: Large Structures]]
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[[Category: Simian 11 rotavirus a]]
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[[Category: Jayaram H]]
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[[Category: Jayaram, H.]]
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[[Category: Patton JT]]
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[[Category: Patton, J T.]]
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[[Category: Prasad BV]]
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[[Category: Prasad, B V.]]
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[[Category: Taraporewala Z]]
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[[Category: Taraporewala, Z.]]
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[[Category: Alpha/beta protein]]
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[[Category: Hit-like fold]]
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[[Category: Octamer]]
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[[Category: Two domain protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 05:58:31 2009''
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Current revision

Non Structural protein encoded by gene segment 8 of rotavirus (NSP2), an NTPase, ssRNA binding and nucleic acid helix-destabilizing protein

PDB ID 1l9v

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