1diw

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{{Seed}}
 
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[[Image:1diw.png|left|200px]]
 
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==THE HC FRAGMENT OF TETANUS TOXIN COMPLEXED WITH GALACTOSE==
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The line below this paragraph, containing "STRUCTURE_1diw", creates the "Structure Box" on the page.
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<StructureSection load='1diw' size='340' side='right'caption='[[1diw]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1diw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Clostridium_tetani Clostridium tetani]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DIW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DIW FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene></td></tr>
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{{STRUCTURE_1diw| PDB=1diw | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1diw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1diw OCA], [https://pdbe.org/1diw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1diw RCSB], [https://www.ebi.ac.uk/pdbsum/1diw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1diw ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TETX_CLOTE TETX_CLOTE] Tetanus toxin acts by inhibiting neurotransmitter release. It binds to peripheral neuronal synapses, is internalized and moves by retrograde transport up the axon into the spinal cord where it can move between postsynaptic and presynaptic neurons. It inhibits neurotransmitter release by acting as a zinc endopeptidase that catalyzes the hydrolysis of the '76-Gln-|-Phe-77' bond of synaptobrevin-2.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/di/1diw_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1diw ConSurf].
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<div style="clear:both"></div>
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===THE HC FRAGMENT OF TETANUS TOXIN COMPLEXED WITH GALACTOSE===
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==See Also==
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*[[Tetanus toxin|Tetanus toxin]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_10722735}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 10722735 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10722735}}
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==About this Structure==
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1DIW is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Clostridium_tetani Clostridium tetani]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DIW OCA].
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==Reference==
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<ref group="xtra">PMID:10722735</ref><references group="xtra"/>
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[[Category: Clostridium tetani]]
[[Category: Clostridium tetani]]
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[[Category: Tentoxilysin]]
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[[Category: Large Structures]]
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[[Category: Black, I.]]
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[[Category: Black I]]
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[[Category: Charles, I G.]]
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[[Category: Charles IG]]
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[[Category: Emsley, P.]]
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[[Category: Emsley P]]
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[[Category: Fairweather, N F.]]
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[[Category: Fairweather NF]]
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[[Category: Fotinou, C.]]
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[[Category: Fotinou C]]
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[[Category: Hewitt, E.]]
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[[Category: Hewitt E]]
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[[Category: Isaacs, N W.]]
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[[Category: Isaacs NW]]
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[[Category: Watts, C.]]
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[[Category: Watts C]]
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[[Category: Beta trefoil]]
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[[Category: Jelly-roll]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 05:59:56 2009''
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Current revision

THE HC FRAGMENT OF TETANUS TOXIN COMPLEXED WITH GALACTOSE

PDB ID 1diw

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