2coq

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{{Seed}}
 
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[[Image:2coq.png|left|200px]]
 
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==Structure of new antigen receptor variable domain from sharks==
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The line below this paragraph, containing "STRUCTURE_2coq", creates the "Structure Box" on the page.
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<StructureSection load='2coq' size='340' side='right'caption='[[2coq]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2coq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Orectolobus_maculatus Orectolobus maculatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2COQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2COQ FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2coq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2coq OCA], [https://pdbe.org/2coq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2coq RCSB], [https://www.ebi.ac.uk/pdbsum/2coq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2coq ProSAT]</span></td></tr>
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{{STRUCTURE_2coq| PDB=2coq | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q8JJ25_9CHON Q8JJ25_9CHON]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/co/2coq_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2coq ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The new antigen receptor (IgNAR) antibodies from sharks are disulphide bonded dimers of two protein chains, each containing one variable and five constant domains. Three types of IgNAR variable domains have been discovered, with Type 3 appearing early in shark development and being overtaken by the antigen-driven affinity-matured Type 1 and 2 response. Here, we have determined the first structure of a naturally occurring Type 2 IgNAR variable domain, and identified the disulphide bond that links and stabilizes the CDR1 and CDR3 loops. This disulphide bridge locks the CDR3 loop in an "upright" conformation in contrast to other shark antibody structures, where a more lateral configuration is observed. Further, we sought to model the Type 3 isotype based on the crystallographic structure reported here. This modeling indicates (1) that internal Type 3-specific residues combine to pack into a compact immunoglobulin core that supports the CDR loop regions, and (2) that despite apparent low-sequence variability, there is sufficient plasticity in the CDR3 loop to form a conformationally diverse antigen-binding surface.
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===Structure of new antigen receptor variable domain from sharks===
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Structure of a shark IgNAR antibody variable domain and modeling of an early-developmental isotype.,Streltsov VA, Carmichael JA, Nuttall SD Protein Sci. 2005 Nov;14(11):2901-9. Epub 2005 Sep 30. PMID:16199666<ref>PMID:16199666</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_16199666}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 2coq" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 16199666 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_16199666}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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2COQ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Orectolobus_maculatus Orectolobus maculatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2COQ OCA].
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==Reference==
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<ref group="xtra">PMID:16199666</ref><references group="xtra"/>
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[[Category: Orectolobus maculatus]]
[[Category: Orectolobus maculatus]]
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[[Category: Carmichael, J A.]]
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[[Category: Carmichael JA]]
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[[Category: Nuttall, S D.]]
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[[Category: Nuttall SD]]
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[[Category: Streltsov, V A.]]
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[[Category: Streltsov VA]]
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[[Category: 12a-9]]
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[[Category: Ig vnar]]
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[[Category: Natural type2]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 06:28:59 2009''
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Current revision

Structure of new antigen receptor variable domain from sharks

PDB ID 2coq

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