3dab

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (15:06, 1 November 2023) (edit) (undo)
 
(9 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:3dab.png|left|200px]]
 
-
<!--
+
==Structure of the human Mdmx protein bound to the p53 tumor suppressor transactivation domain==
-
The line below this paragraph, containing "STRUCTURE_3dab", creates the "Structure Box" on the page.
+
<StructureSection load='3dab' size='340' side='right'caption='[[3dab]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[3dab]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DAB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3DAB FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
-
-->
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3dab FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dab OCA], [https://pdbe.org/3dab PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3dab RCSB], [https://www.ebi.ac.uk/pdbsum/3dab PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3dab ProSAT]</span></td></tr>
-
{{STRUCTURE_3dab| PDB=3dab | SCENE= }}
+
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/MDM4_HUMAN MDM4_HUMAN] Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions.<ref>PMID:16163388</ref> <ref>PMID:16511572</ref>
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/da/3dab_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3dab ConSurf].
 +
<div style="clear:both"></div>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
The Mdmx oncoprotein has only recently emerged as a critical-independent to Mdm2-regulator of p53 activation. We have determined the crystal structure of the N-terminal domain of human Mdmx bound to a 15-residue transactivation domain peptide of human p53. The structure shows why antagonists of the Mdm2 binding to p53 are ineffective in the Mdmx-p53 interaction.
-
===Structure of the human Mdmx protein bound to the p53 tumor suppressor transactivation domain===
+
Structure of the human Mdmx protein bound to the p53 tumor suppressor transactivation domain.,Popowicz GM, Czarna A, Holak TA Cell Cycle. 2008 Aug;7(15):2441-3. Epub 2008 May 27. PMID:18677113<ref>PMID:18677113</ref>
 +
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 +
</div>
 +
<div class="pdbe-citations 3dab" style="background-color:#fffaf0;"></div>
-
<!--
+
==See Also==
-
The line below this paragraph, {{ABSTRACT_PUBMED_18677113}}, adds the Publication Abstract to the page
+
*[[MDM4|MDM4]]
-
(as it appears on PubMed at http://www.pubmed.gov), where 18677113 is the PubMed ID number.
+
== References ==
-
-->
+
<references/>
-
{{ABSTRACT_PUBMED_18677113}}
+
__TOC__
-
 
+
</StructureSection>
-
==About this Structure==
+
-
3DAB is a 8 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DAB OCA].
+
-
 
+
-
==Reference==
+
-
<ref group="xtra">PMID:18677113</ref><references group="xtra"/>
+
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Czarna, A.]]
+
[[Category: Large Structures]]
-
[[Category: Holak, T A.]]
+
[[Category: Czarna A]]
-
[[Category: Popowicz, G M.]]
+
[[Category: Holak TA]]
-
[[Category: Apoptosis]]
+
[[Category: Popowicz GM]]
-
[[Category: Cell cycle]]
+
-
[[Category: Disease mutation]]
+
-
[[Category: Dna-binding]]
+
-
[[Category: Hdm2]]
+
-
[[Category: Hdm4]]
+
-
[[Category: Hdmx]]
+
-
[[Category: Mdm-4]]
+
-
[[Category: Mdm-x]]
+
-
[[Category: Mdm2]]
+
-
[[Category: Mdm4]]
+
-
[[Category: Mdmx]]
+
-
[[Category: Nucleus]]
+
-
[[Category: Oncogene]]
+
-
[[Category: P53]]
+
-
[[Category: Transcription]]
+
-
[[Category: Tumor]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 06:33:03 2009''
+

Current revision

Structure of the human Mdmx protein bound to the p53 tumor suppressor transactivation domain

PDB ID 3dab

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3dab"
Personal tools