2hex

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
(New page: 200px<br /><applet load="2hex" size="450" color="white" frame="true" align="right" spinBox="true" caption="2hex, resolution 2.10&Aring;" /> '''DECAMERS OBSERVED IN...)
Current revision (01:01, 21 November 2024) (edit) (undo)
 
(17 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:2hex.jpg|left|200px]]<br /><applet load="2hex" size="450" color="white" frame="true" align="right" spinBox="true"
 
-
caption="2hex, resolution 2.10&Aring;" />
 
-
'''DECAMERS OBSERVED IN THE CRYSTALS OF BOVINE PANCREATIC TRYPSIN INHIBITOR'''<br />
 
-
==Overview==
+
==DECAMERS OBSERVED IN THE CRYSTALS OF BOVINE PANCREATIC TRYPSIN INHIBITOR==
-
The structure of bovine pancreatic trypsin inhibitor (BPTI) has been, solved at 2.1 A resolution in a new crystal form (space group P6422 with, unit-cell dimensions a = b = 95.0, c = 158.1 A). The asymmetric unit is a, pentamer, but a decamer is created by application of crystallographic, symmetry. The decamer of BPTI is only the fourth such assembly reported to, date in the Protein Data Bank.
+
<StructureSection load='2hex' size='340' side='right'caption='[[2hex]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[2hex]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HEX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HEX FirstGlance]. <br>
 +
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
 +
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2hex FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hex OCA], [https://pdbe.org/2hex PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2hex RCSB], [https://www.ebi.ac.uk/pdbsum/2hex PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2hex ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/BPT1_BOVIN BPT1_BOVIN] Inhibits trypsin, kallikrein, chymotrypsin, and plasmin.
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/he/2hex_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2hex ConSurf].
 +
<div style="clear:both"></div>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
The structure of bovine pancreatic trypsin inhibitor (BPTI) has been solved at 2.1 A resolution in a new crystal form (space group P6422 with unit-cell dimensions a = b = 95.0, c = 158.1 A). The asymmetric unit is a pentamer, but a decamer is created by application of crystallographic symmetry. The decamer of BPTI is only the fourth such assembly reported to date in the Protein Data Bank.
-
==About this Structure==
+
Decamers observed in the crystals of bovine pancreatic trypsin inhibitor.,Lubkowski J, Wlodawer A Acta Crystallogr D Biol Crystallogr. 1999 Jan;55(Pt 1):335-7. Epub 1999, Jan 1. PMID:10089443<ref>PMID:10089443</ref>
-
2HEX is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] with SO4 as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2HEX OCA].
+
-
==Reference==
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-
Decamers observed in the crystals of bovine pancreatic trypsin inhibitor., Lubkowski J, Wlodawer A, Acta Crystallogr D Biol Crystallogr. 1999 Jan;55(Pt 1):335-7. Epub 1999, Jan 1. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10089443 10089443]
+
</div>
-
[[Category: Bos taurus]]
+
<div class="pdbe-citations 2hex" style="background-color:#fffaf0;"></div>
-
[[Category: Single protein]]
+
-
[[Category: Lubkowski, J.]]
+
-
[[Category: Wlodawer, A.]]
+
-
[[Category: SO4]]
+
-
[[Category: blood clotting]]
+
-
[[Category: bovine pancreatic trypsin inhibitor]]
+
-
[[Category: pentameric molecule]]
+
-
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 11:42:29 2007''
+
==See Also==
 +
*[[BPTI 3D structures|BPTI 3D structures]]
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Bos taurus]]
 +
[[Category: Large Structures]]
 +
[[Category: Lubkowski J]]
 +
[[Category: Wlodawer A]]

Current revision

DECAMERS OBSERVED IN THE CRYSTALS OF BOVINE PANCREATIC TRYPSIN INHIBITOR

PDB ID 2hex

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2hex"
Personal tools