3dpu

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{{Seed}}
 
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[[Image:3dpu.png|left|200px]]
 
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==RocCOR domain tandem of Rab family protein (Roco)==
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The line below this paragraph, containing "STRUCTURE_3dpu", creates the "Structure Box" on the page.
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<StructureSection load='3dpu' size='340' side='right'caption='[[3dpu]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3dpu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Chlorobaculum_tepidum Chlorobaculum tepidum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DPU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3DPU FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3dpu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dpu OCA], [https://pdbe.org/3dpu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3dpu RCSB], [https://www.ebi.ac.uk/pdbsum/3dpu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3dpu ProSAT]</span></td></tr>
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{{STRUCTURE_3dpu| PDB=3dpu | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q8KC98_CHLTE Q8KC98_CHLTE]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dp/3dpu_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3dpu ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Ras of complex proteins (Roc) belongs to the superfamily of Ras-related small G-proteins that always occurs in tandem with the C-terminal of Roc (COR) domain. This Roc-COR tandem is found in the bacterial and eukaryotic world. Its most prominent member is the leucine-rich repeat kinase LRRK2, which is mutated and activated in Parkinson patients. Here, we investigated biochemically and structurally the Roco protein from Chlorobium tepidum. We show that Roc is highly homologous to Ras, whereas the COR domain is a dimerisation device. The juxtaposition of the G-domains and mutational analysis suggest that the Roc GTPase reaction is stimulated and/or regulated by dimerisation in a nucleotide-dependent manner. The region most conserved between bacteria and man is the interface between Roc and COR, where single-point Parkinson mutations of the Roc and COR domains are in close proximity. The analogous mutations in C. tepidum Roc-COR decrease the GTPase reaction rate, most likely due to a modification of the interaction between the Roc and COR domains.
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===RocCOR domain tandem of Rab family protein (Roco)===
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Structure of the Roc-COR domain tandem of C. tepidum, a prokaryotic homologue of the human LRRK2 Parkinson kinase.,Gotthardt K, Weyand M, Kortholt A, Van Haastert PJ, Wittinghofer A EMBO J. 2008 Aug 20;27(16):2239-49. Epub 2008 Jul 24. PMID:18650931<ref>PMID:18650931</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_18650931}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 3dpu" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 18650931 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_18650931}}
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__TOC__
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</StructureSection>
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==About this Structure==
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3DPU is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Chlorobaculum_tepidum Chlorobaculum tepidum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DPU OCA].
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==Reference==
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<ref group="xtra">PMID:18650931</ref><references group="xtra"/>
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[[Category: Chlorobaculum tepidum]]
[[Category: Chlorobaculum tepidum]]
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[[Category: Gotthardt, K.]]
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[[Category: Large Structures]]
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[[Category: Haastert, P J.M Van.]]
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[[Category: Gotthardt K]]
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[[Category: Kortholt, A.]]
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[[Category: Kortholt A]]
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[[Category: Weyand, M.]]
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[[Category: Van Haastert PJM]]
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[[Category: Wittinghofer, A.]]
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[[Category: Weyand M]]
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[[Category: Cor]]
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[[Category: Wittinghofer A]]
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[[Category: G-domain]]
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[[Category: Gtp-binding]]
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[[Category: Nucleotide-binding]]
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[[Category: Roccor]]
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[[Category: Signaling protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 06:45:46 2009''
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Current revision

RocCOR domain tandem of Rab family protein (Roco)

PDB ID 3dpu

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