2z36

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{{Seed}}
 
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[[Image:2z36.png|left|200px]]
 
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==Crystal structure of cytochrome P450 MoxA from Nonomuraea recticatena (CYP105)==
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The line below this paragraph, containing "STRUCTURE_2z36", creates the "Structure Box" on the page.
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<StructureSection load='2z36' size='340' side='right'caption='[[2z36]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2z36]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Nonomuraea_recticatena Nonomuraea recticatena]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z36 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Z36 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene></td></tr>
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{{STRUCTURE_2z36| PDB=2z36 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2z36 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2z36 OCA], [https://pdbe.org/2z36 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2z36 RCSB], [https://www.ebi.ac.uk/pdbsum/2z36 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2z36 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q2L6S8_9ACTN Q2L6S8_9ACTN]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z3/2z36_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2z36 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Cytochrome P450 MoxA (P450moxA) from a rare actinomycete Nonomuraea recticatena belongs to the CYP105 family and exhibits remarkably broad substrate specificity. Here, we demonstrate that P450moxA acts on several luciferin derivatives, which were originally identified as substrates of the human microsomal P450s. We also describe the crystal structure of P450moxA in substrate-free form. Structural comparison with various bacterial and human microsomal P450s reveals that the P450moxA structure is most closely related to that of the fungal nitric oxide reductase P450nor (CYP55A1). Final refined model of P450moxA comprises almost all the residues, including the "BC-loop" and "FG-loop" regions pivotal for substrate recognition, and the current structure thus defines a well-ordered substrate-binding pocket. Clear electron density map reveals that the MES molecule is bound to the substrate-binding site, and the sixth coordination position of the heme iron is not occupied by a water molecule, probably due to the presence of MES molecule in the vicinity of the heme. The unexpected binding of the MES molecule might reflect the ability of P450moxA to accommodate a broad range of structurally diverse compounds.
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===Crystal structure of cytochrome P450 MoxA from Nonomuraea recticatena (CYP105)===
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Crystal structure of cytochrome P450 MoxA from Nonomuraea recticatena (CYP105).,Yasutake Y, Imoto N, Fujii Y, Fujii T, Arisawa A, Tamura T Biochem Biophys Res Commun. 2007 Oct 5;361(4):876-82. Epub 2007 Jul 25. PMID:17679139<ref>PMID:17679139</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_17679139}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 2z36" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 17679139 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_17679139}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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2Z36 is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Nonomuraea_recticatena Nonomuraea recticatena]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z36 OCA].
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==Reference==
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<ref group="xtra">PMID:17679139</ref><references group="xtra"/>
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[[Category: Nonomuraea recticatena]]
[[Category: Nonomuraea recticatena]]
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[[Category: Arisawa, A.]]
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[[Category: Arisawa A]]
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[[Category: Fujii, T.]]
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[[Category: Fujii T]]
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[[Category: Fujii, Y.]]
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[[Category: Fujii Y]]
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[[Category: Tamura, T.]]
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[[Category: Tamura T]]
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[[Category: Yasutake, Y.]]
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[[Category: Yasutake Y]]
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[[Category: Cyp105]]
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[[Category: Oxidoreductase]]
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[[Category: P450]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 06:52:51 2009''
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Current revision

Crystal structure of cytochrome P450 MoxA from Nonomuraea recticatena (CYP105)

PDB ID 2z36

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