1gcf

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[[Image:1gcf.png|left|200px]]
 
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==NMR STRUCTURE OF THE C-TERMINAL DOMAIN OF THE LIGAND-BINDING REGION OF MURINE GRANULOCYTE COLONY-STIMULATING FACTOR RECEPTOR, 12 STRUCTURES==
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The line below this paragraph, containing "STRUCTURE_1gcf", creates the "Structure Box" on the page.
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<StructureSection load='1gcf' size='340' side='right'caption='[[1gcf]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1gcf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GCF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1GCF FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 12 models</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1gcf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gcf OCA], [https://pdbe.org/1gcf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1gcf RCSB], [https://www.ebi.ac.uk/pdbsum/1gcf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1gcf ProSAT]</span></td></tr>
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{{STRUCTURE_1gcf| PDB=1gcf | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CSF3R_MOUSE CSF3R_MOUSE] Receptor for granulocyte colony-stimulating factor (CSF3). In addition it may function in some adhesion or recognition events at the cell surface.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gc/1gcf_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1gcf ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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We have determined the NMR structure of a ligand-binding domain of the granulocyte colony-stimulating factor (G-CSF) receptor, containing the highly conserved WSxWS motif. The domain consists of seven beta-strands with the fibronectin type III-like topology seen in several cytokine receptors. Comparisons between the spectra of the 15N-labelled domain with and without G-CSF indicate that the major ligand-recognition site is on the FG loop just upstream of the WSxWS sequence, and not on the BC loop which is mainly used in the growth hormone system. The WSxWS residues are suggested to contribute to ligand-recognition and to the protein architecture of the G-CSF receptor.
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===NMR STRUCTURE OF THE C-TERMINAL DOMAIN OF THE LIGAND-BINDING REGION OF MURINE GRANULOCYTE COLONY-STIMULATING FACTOR RECEPTOR, 12 STRUCTURES===
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Solution structure of an extracellular domain containing the WSxWS motif of the granulocyte colony-stimulating factor receptor and its interaction with ligand.,Yamasaki K, Naito S, Anaguchi H, Ohkubo T, Ota Y Nat Struct Biol. 1997 Jun;4(6):498-504. PMID:9187659<ref>PMID:9187659</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 1gcf" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_9187659}}, adds the Publication Abstract to the page
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*[[Colony-stimulating factor 3D structures|Colony-stimulating factor 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 9187659 is the PubMed ID number.
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*[[Colony-stimulating factor receptor 3D structures|Colony-stimulating factor receptor 3D structures]]
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== References ==
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{{ABSTRACT_PUBMED_9187659}}
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<references/>
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__TOC__
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==About this Structure==
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</StructureSection>
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1GCF is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GCF OCA].
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[[Category: Large Structures]]
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==Reference==
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<ref group="xtra">PMID:9187659</ref><references group="xtra"/>
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[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Anaguchi, H.]]
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[[Category: Anaguchi H]]
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[[Category: Naito, S.]]
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[[Category: Naito S]]
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[[Category: Ohkubo, T.]]
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[[Category: Ohkubo T]]
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[[Category: Ota, Y.]]
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[[Category: Ota Y]]
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[[Category: Yamasaki, K.]]
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[[Category: Yamasaki K]]
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[[Category: Binding protein]]
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[[Category: Cytokine receptor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 06:54:43 2009''
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Current revision

NMR STRUCTURE OF THE C-TERMINAL DOMAIN OF THE LIGAND-BINDING REGION OF MURINE GRANULOCYTE COLONY-STIMULATING FACTOR RECEPTOR, 12 STRUCTURES

PDB ID 1gcf

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