2vd3

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{{Seed}}
 
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[[Image:2vd3.png|left|200px]]
 
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==The structure of histidine inhibited HisG from Methanobacterium thermoautotrophicum==
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The line below this paragraph, containing "STRUCTURE_2vd3", creates the "Structure Box" on the page.
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<StructureSection load='2vd3' size='340' side='right'caption='[[2vd3]], [[Resolution|resolution]] 2.45&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2vd3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Methanothermobacter_thermautotrophicus_str._Delta_H Methanothermobacter thermautotrophicus str. Delta H]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VD3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VD3 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.45&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=HIS:HISTIDINE'>HIS</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=MRD:(4R)-2-METHYLPENTANE-2,4-DIOL'>MRD</scene></td></tr>
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{{STRUCTURE_2vd3| PDB=2vd3 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vd3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vd3 OCA], [https://pdbe.org/2vd3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vd3 RCSB], [https://www.ebi.ac.uk/pdbsum/2vd3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vd3 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/HIS1_METTH HIS1_METTH] Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vd/2vd3_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2vd3 ConSurf].
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<div style="clear:both"></div>
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===THE STRUCTURE OF HISTIDINE INHIBITED HISG FROM METHANOBACTERIUM THERMOAUTOTROPHICUM===
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==See Also==
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*[[ATP phosphoribosyl transferase 3D structures|ATP phosphoribosyl transferase 3D structures]]
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__TOC__
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==About this Structure==
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</StructureSection>
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2VD3 is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Methanothermobacter_thermautotrophicus Methanothermobacter thermautotrophicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VD3 OCA].
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[[Category: Large Structures]]
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[[Category: ATP phosphoribosyltransferase]]
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[[Category: Methanothermobacter thermautotrophicus str. Delta H]]
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[[Category: Methanothermobacter thermautotrophicus]]
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[[Category: Lapthorn AJ]]
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[[Category: Lapthorn, A J.]]
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[[Category: Lohkamp B]]
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[[Category: Lohkamp, B.]]
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[[Category: Schweikert T]]
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[[Category: Schweikert, T.]]
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[[Category: Amino-acid biosynthesis]]
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[[Category: Atp phosphoribosyl transferase]]
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[[Category: Cytoplasm]]
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[[Category: Glycosyltransferase]]
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[[Category: Hisg]]
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[[Category: Histidine]]
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[[Category: Histidine biosynthesis]]
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[[Category: Magnesium]]
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[[Category: Metal-binding]]
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[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 07:38:36 2009''
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Current revision

The structure of histidine inhibited HisG from Methanobacterium thermoautotrophicum

PDB ID 2vd3

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