2e2s

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{{Seed}}
 
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[[Image:2e2s.png|left|200px]]
 
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==Solution structure of agelenin, an insecticidal peptide from the venom of Agelena opulenta==
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The line below this paragraph, containing "STRUCTURE_2e2s", creates the "Structure Box" on the page.
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<StructureSection load='2e2s' size='340' side='right'caption='[[2e2s]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2e2s]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Allagelena_opulenta Allagelena opulenta]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E2S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2E2S FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
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{{STRUCTURE_2e2s| PDB=2e2s | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2e2s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e2s OCA], [https://pdbe.org/2e2s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2e2s RCSB], [https://www.ebi.ac.uk/pdbsum/2e2s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2e2s ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TXAG_ALLOP TXAG_ALLOP] Insect-selective toxin causing rapid but reversible paralysis in crickets. Suppresses the excitatory postsynaptic potentials evoked in lobster neuromuscular synaptic preparations, possibly by blocking the presynaptic calcium channel (Cav). Induces instantaneous reversible paralysis when injected into crickets.<ref>PMID:17644092</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e2/2e2s_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2e2s ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Agelenin, isolated from the Agelenidae spider Agelena opulenta, is a peptide composed of 35 amino acids. We determined the three-dimensional structure of agelenin using two-dimensional NMR spectroscopy. The structure is composed of a short antiparallel beta-sheet and four beta-turns, which are stabilized by three disulfide bonds. Agelenin has characteristic residues, Phe9, Ser28 and Arg33, which are arranged similarly to the pharmacophore of the insect channel inhibitor, omega-atracotoxin-Hv1a. These observations suggest that agelenin and omega-atracotoxin-Hv1a bind to insect calcium channels in a similar manner. We also suggest that another mode of action may operate in the channel inhibition by omega-agatoxin-IVA and omega-atracotoxin-Hv2a.
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===Solution structure of agelenin, an insecticidal peptide from the venom of Agelena opulenta===
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Solution structure of agelenin, an insecticidal peptide isolated from the spider Agelena opulenta, and its structural similarities to insect-specific calcium channel inhibitors.,Yamaji N, Sugase K, Nakajima T, Miki T, Wakamori M, Mori Y, Iwashita T FEBS Lett. 2007 Aug 7;581(20):3789-94. Epub 2007 Jul 10. PMID:17644092<ref>PMID:17644092</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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The line below this paragraph, {{ABSTRACT_PUBMED_17644092}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 2e2s" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 17644092 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_17644092}}
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__TOC__
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</StructureSection>
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==About this Structure==
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2E2S is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Allagelena_opulenta Allagelena opulenta]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E2S OCA].
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==Reference==
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<ref group="xtra">PMID:17644092</ref><references group="xtra"/>
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[[Category: Allagelena opulenta]]
[[Category: Allagelena opulenta]]
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[[Category: Yamaji, N.]]
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[[Category: Large Structures]]
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[[Category: Cystine knot]]
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[[Category: Yamaji N]]
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[[Category: Presynaptic calcium channel inhibitor]]
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[[Category: Toxin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 07:42:20 2009''
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Current revision

Solution structure of agelenin, an insecticidal peptide from the venom of Agelena opulenta

PDB ID 2e2s

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