2jd3

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{{Seed}}
 
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[[Image:2jd3.png|left|200px]]
 
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==ParR from plasmid pB171==
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The line below this paragraph, containing "STRUCTURE_2jd3", creates the "Structure Box" on the page.
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<StructureSection load='2jd3' size='340' side='right'caption='[[2jd3]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2jd3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JD3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JD3 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jd3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jd3 OCA], [https://pdbe.org/2jd3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jd3 RCSB], [https://www.ebi.ac.uk/pdbsum/2jd3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jd3 ProSAT]</span></td></tr>
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{{STRUCTURE_2jd3| PDB=2jd3 | SCENE= }}
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</table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jd/2jd3_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jd3 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Accurate DNA partition at cell division is vital to all living organisms. In bacteria, this process can involve partition loci, which are found on both chromosomes and plasmids. The initial step in Escherichia coli plasmid R1 partition involves the formation of a partition complex between the DNA-binding protein ParR and its cognate centromere site parC on the DNA. The partition complex is recognized by a second partition protein, the actin-like ATPase ParM, which forms filaments required for the active bidirectional movement of DNA replicates. Here, we present the 2.8 A crystal structure of ParR from E. coli plasmid pB171. ParR forms a tight dimer resembling a large family of dimeric ribbon-helix-helix (RHH)2 site-specific DNA-binding proteins. Crystallographic and electron microscopic data further indicate that ParR dimers assemble into a helix structure with DNA-binding sites facing outward. Genetic and biochemical experiments support a structural arrangement in which the centromere-like parC DNA is wrapped around a ParR protein scaffold. This structure holds implications for how ParM polymerization drives active DNA transport during plasmid partition.
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===PARR FROM PLASMID PB171===
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Structural analysis of the ParR/parC plasmid partition complex.,Moller-Jensen J, Ringgaard S, Mercogliano CP, Gerdes K, Lowe J EMBO J. 2007 Oct 17;26(20):4413-22. Epub 2007 Sep 27. PMID:17898804<ref>PMID:17898804</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_17898804}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 2jd3" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 17898804 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_17898804}}
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__TOC__
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</StructureSection>
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==About this Structure==
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2JD3 is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JD3 OCA].
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==Reference==
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<ref group="xtra">PMID:17898804</ref><references group="xtra"/>
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[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Lowe, J.]]
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[[Category: Large Structures]]
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[[Category: Moller-Jensen, J.]]
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[[Category: Lowe J]]
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[[Category: Actin-like filament]]
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[[Category: Moller-Jensen J]]
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[[Category: Dna binding]]
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[[Category: Dna binding protein]]
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[[Category: Parm]]
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[[Category: Plasmid]]
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[[Category: Plasmid segregation]]
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[[Category: Rhh2]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 08:05:00 2009''
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Current revision

ParR from plasmid pB171

PDB ID 2jd3

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