1gxx

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{{Seed}}
 
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[[Image:1gxx.png|left|200px]]
 
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==Solution structure of lysozyme at low and high pressure==
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The line below this paragraph, containing "STRUCTURE_1gxx", creates the "Structure Box" on the page.
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<StructureSection load='1gxx' size='340' side='right'caption='[[1gxx]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1gxx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GXX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1GXX FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 1 model</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1gxx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gxx OCA], [https://pdbe.org/1gxx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1gxx RCSB], [https://www.ebi.ac.uk/pdbsum/1gxx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1gxx ProSAT]</span></td></tr>
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{{STRUCTURE_1gxx| PDB=1gxx | SCENE= }}
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</table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gx/1gxx_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1gxx ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The "rules" governing protein structure and stability are still poorly understood. Important clues have come from proteins that operate under extreme conditions, because these clarify the physical constraints on proteins. One obvious extreme is pressure, but so far little is known of the behavior of proteins under pressure, largely for technical reasons. We have therefore developed new methodology for calculating structure change in solution with pressure, using NMR chemical shift changes, and we report the change in structure of lysozyme on going from 30 bar to 2000 bar, this being the first solution structure of a globular protein under pressure. The alpha-helical domain is compressed by approximately 1%, due to tighter packing between helices. The interdomain region is also compressed. By contrast, the beta-sheet domain displays very little overall compression, but undergoes more structural distortion than the alpha-domain. The largest volume changes tend to occur close to hydrated cavities. Because isothermal compressibility is related to volume fluctuation, this suggests that buried water molecules play an important role in conformational fluctuation at normal pressures, and are implicated as the nucleation sites for structural changes leading to pressure denaturation or channel opening.
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===SOLUTION STRUCTURE OF LYSOZYME AT LOW AND HIGH PRESSURE===
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Pressure-dependent changes in the solution structure of hen egg-white lysozyme.,Refaee M, Tezuka T, Akasaka K, Williamson MP J Mol Biol. 2003 Apr 4;327(4):857-65. PMID:12654268<ref>PMID:12654268</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 1gxx" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_12654268}}, adds the Publication Abstract to the page
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*[[Lysozyme 3D structures|Lysozyme 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 12654268 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_12654268}}
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__TOC__
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</StructureSection>
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==About this Structure==
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1GXX is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GXX OCA].
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==Reference==
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<ref group="xtra">PMID:12654268</ref><references group="xtra"/>
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[[Category: Gallus gallus]]
[[Category: Gallus gallus]]
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[[Category: Lysozyme]]
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[[Category: Large Structures]]
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[[Category: Akasaka, K.]]
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[[Category: Akasaka K]]
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[[Category: Refaee, M.]]
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[[Category: Refaee M]]
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[[Category: Williamson, M.]]
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[[Category: Williamson M]]
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[[Category: Allergen]]
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[[Category: Bacteriolytic enzyme]]
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[[Category: Egg-white]]
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[[Category: Glycosidase]]
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[[Category: Hydrolase]]
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[[Category: Saccharide degradation]]
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[[Category: Signal]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 08:21:08 2009''
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Current revision

Solution structure of lysozyme at low and high pressure

PDB ID 1gxx

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OCA

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