1fs2

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{{Seed}}
 
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[[Image:1fs2.png|left|200px]]
 
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==INSIGHTS INTO SCF UBIQUITIN LIGASES FROM THE STRUCTURE OF THE SKP1-SKP2 COMPLEX==
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The line below this paragraph, containing "STRUCTURE_1fs2", creates the "Structure Box" on the page.
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<StructureSection load='1fs2' size='340' side='right'caption='[[1fs2]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1fs2]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FS2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FS2 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1fs2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fs2 OCA], [https://pdbe.org/1fs2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1fs2 RCSB], [https://www.ebi.ac.uk/pdbsum/1fs2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1fs2 ProSAT]</span></td></tr>
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{{STRUCTURE_1fs2| PDB=1fs2 | SCENE= }}
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</table>
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== Function ==
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===INSIGHTS INTO SCF UBIQUITIN LIGASES FROM THE STRUCTURE OF THE SKP1-SKP2 COMPLEX===
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[https://www.uniprot.org/uniprot/SKP2_HUMAN SKP2_HUMAN] Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. Specifically recognizes phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. Degradation of CDKN1B/p27kip also requires CKS1. Recognizes target proteins ORC1, CDT1, RBL2, MLL, CDK9, RAG2, FOXO1, UBP43, and probably MYC, TOB1 and TAL1. Degradation of TAL1 also requires STUB1. Recognizes CDKN1A in association with CCNE1 or CCNE2 and CDK2. Promotes ubiquitination and destruction of CDH1 in a CK1-Dependent Manner, thereby regulating cell migration.<ref>PMID:12435635</ref> <ref>PMID:11931757</ref> <ref>PMID:12840033</ref> <ref>PMID:12769844</ref> <ref>PMID:15342634</ref> <ref>PMID:16262255</ref> <ref>PMID:15949444</ref> <ref>PMID:16103164</ref> <ref>PMID:15668399</ref> <ref>PMID:16951159</ref> <ref>PMID:16581786</ref> <ref>PMID:17908926</ref> <ref>PMID:17962192</ref> <ref>PMID:22770219</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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The line below this paragraph, {{ABSTRACT_PUBMED_11099048}}, adds the Publication Abstract to the page
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<jmolCheckbox>
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(as it appears on PubMed at http://www.pubmed.gov), where 11099048 is the PubMed ID number.
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fs/1fs2_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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{{ABSTRACT_PUBMED_11099048}}
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==About this Structure==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1fs2 ConSurf].
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1FS2 is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FS2 OCA].
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<div style="clear:both"></div>
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:11099048</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Bowen, Z.]]
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[[Category: Large Structures]]
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[[Category: Carrano, A C.]]
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[[Category: Bowen Z]]
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[[Category: Elledge, S J.]]
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[[Category: Carrano AC]]
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[[Category: Finnin, M S.]]
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[[Category: Elledge SJ]]
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[[Category: Harper, J W.]]
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[[Category: Finnin MS]]
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[[Category: Jeffrey, P D.]]
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[[Category: Harper JW]]
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[[Category: Kinnucan, E R.E.]]
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[[Category: Jeffrey PD]]
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[[Category: Pagano, M.]]
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[[Category: Kinnucan ERE]]
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[[Category: Pavletich, N P.]]
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[[Category: Pagano M]]
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[[Category: Schulman, B A.]]
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[[Category: Pavletich NP]]
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[[Category: E3]]
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[[Category: Schulman BA]]
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[[Category: F-box]]
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[[Category: Leucine-rich repeat]]
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[[Category: Lrr]]
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[[Category: Scf]]
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[[Category: Skp1]]
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[[Category: Skp2]]
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[[Category: Ubiquitin]]
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[[Category: Ubiquitin protein ligase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 08:24:42 2009''
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Current revision

INSIGHTS INTO SCF UBIQUITIN LIGASES FROM THE STRUCTURE OF THE SKP1-SKP2 COMPLEX

PDB ID 1fs2

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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