2p31

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (10:53, 30 August 2023) (edit) (undo)
 
(9 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:2p31.png|left|200px]]
 
-
<!--
+
==Crystal structure of human glutathione peroxidase 7==
-
The line below this paragraph, containing "STRUCTURE_2p31", creates the "Structure Box" on the page.
+
<StructureSection load='2p31' size='340' side='right'caption='[[2p31]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[2p31]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P31 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2P31 FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
-
{{STRUCTURE_2p31| PDB=2p31 | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2p31 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2p31 OCA], [https://pdbe.org/2p31 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2p31 RCSB], [https://www.ebi.ac.uk/pdbsum/2p31 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2p31 ProSAT]</span></td></tr>
 +
</table>
 +
== Disease ==
 +
[https://www.uniprot.org/uniprot/GPX7_HUMAN GPX7_HUMAN] Defects in GPX7 are a cause of Barrett esophagus (BE) [MIM:[https://omim.org/entry/614266 614266]. A condition characterized by a metaplastic change in which normal esophageal squamous epithelium is replaced by a columnar and intestinal-type epithelium. Patients with Barrett esophagus have an increased risk of esophageal adenocarcinoma. The main cause of Barrett esophagus is gastroesophageal reflux. The retrograde movement of acid and bile salts from the stomach into the esophagus causes prolonged injury to the esophageal epithelium and induces chronic esophagitis, which in turn is believed to trigger the pathologic changes. Note=The pathologic mechanisms leading to Barrett esophagus involve GPX7 dysfunction that results in higher levels of hydrogen peroxide and ROS-induced oxidative stress and DNA damage in esophageal cells.
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/GPX7_HUMAN GPX7_HUMAN] It protects esophageal epithelia from hydrogen peroxide-induced oxidative stress. It suppresses acidic bile acid-induced reactive oxigen species (ROS) and protects against oxidative DNA damage and double-strand breaks.
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/p3/2p31_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2p31 ConSurf].
 +
<div style="clear:both"></div>
-
===Crystal structure of human glutathione peroxidase 7===
+
==See Also==
-
 
+
*[[Glutathione peroxidase|Glutathione peroxidase]]
-
 
+
__TOC__
-
==About this Structure==
+
</StructureSection>
-
2P31 is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P31 OCA].
+
-
[[Category: Glutathione peroxidase]]
+
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Arrowsmith, C H.]]
+
[[Category: Large Structures]]
-
[[Category: Delft, F von.]]
+
[[Category: Arrowsmith CH]]
-
[[Category: Edwards, A.]]
+
[[Category: Edwards A]]
-
[[Category: Gileadi, O.]]
+
[[Category: Gileadi O]]
-
[[Category: Johansson, C.]]
+
[[Category: Johansson C]]
-
[[Category: Kavanagh, K L.]]
+
[[Category: Kavanagh KL]]
-
[[Category: Kochan, G.]]
+
[[Category: Kochan G]]
-
[[Category: Oppermann, U.]]
+
[[Category: Oppermann U]]
-
[[Category: Papagrigoriou, E.]]
+
[[Category: Papagrigoriou E]]
-
[[Category: SGC, Structural Genomics Consortium.]]
+
[[Category: Sundstrom M]]
-
[[Category: Sundstrom, M.]]
+
[[Category: Umeano C]]
-
[[Category: Umeano, C.]]
+
[[Category: Weigelt J]]
-
[[Category: Weigelt, J.]]
+
[[Category: Von Delft F]]
-
[[Category: Npgpx]]
+
-
[[Category: Phospholipid hydroperoxidase]]
+
-
[[Category: Sgc]]
+
-
[[Category: Structural genomic]]
+
-
[[Category: Structural genomics consortium]]
+
-
[[Category: Thioredoxin fold]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 08:38:14 2009''
+

Current revision

Crystal structure of human glutathione peroxidase 7

PDB ID 2p31

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2p31"
Personal tools