2cc1

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{{Seed}}
 
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[[Image:2cc1.png|left|200px]]
 
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==Crystal structure of the class A beta-lactamase from Mycobacterium fortuitum==
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The line below this paragraph, containing "STRUCTURE_2cc1", creates the "Structure Box" on the page.
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<StructureSection load='2cc1' size='340' side='right'caption='[[2cc1]], [[Resolution|resolution]] 2.13&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2cc1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycolicibacterium_fortuitum Mycolicibacterium fortuitum]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1mfo 1mfo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CC1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CC1 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.13&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cc1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cc1 OCA], [https://pdbe.org/2cc1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cc1 RCSB], [https://www.ebi.ac.uk/pdbsum/2cc1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cc1 ProSAT]</span></td></tr>
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{{STRUCTURE_2cc1| PDB=2cc1 | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/BLAF_MYCFO BLAF_MYCFO]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cc/2cc1_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2cc1 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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beta-Lactamases are the main cause of bacterial resistance to penicillins and cephalosporins. Class A beta-lactamases, the largest group of beta-lactamases, have been found in many bacterial strains, including mycobacteria, for which no beta-lactamase structure has been previously reported. The crystal structure of the class A beta-lactamase from Mycobacterium fortuitum (MFO) has been solved at 2.13-A resolution. The enzyme is a chromosomally encoded broad-spectrum beta-lactamase with low specific activity on cefotaxime. Specific features of the active site of the class A beta-lactamase from M. fortuitum are consistent with its specificity profile. Arg278 and Ser237 favor cephalosporinase activity and could explain its broad substrate activity. The MFO active site presents similarities with the CTX-M type extended-spectrum beta-lactamases but lacks a specific feature of these enzymes, the VNYN motif (residues 103 to 106), which confers on CTX-M-type extended-spectrum beta-lactamases a more efficient cefotaximase activity.
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===CRYSTAL STRUCTURE OF THE CLASS A BETA-LACTAMASE FROM MYCOBACTERIUM FORTUITUM===
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Crystal structure of the Mycobacterium fortuitum class A beta-lactamase: structural basis for broad substrate specificity.,Sauvage E, Fonze E, Quinting B, Galleni M, Frere JM, Charlier P Antimicrob Agents Chemother. 2006 Jul;50(7):2516-21. PMID:16801434<ref>PMID:16801434</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2cc1" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_16801434}}, adds the Publication Abstract to the page
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*[[Beta-lactamase 3D structures|Beta-lactamase 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 16801434 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_16801434}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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2CC1 is a 1 chain structure. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1mfo 1mfo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CC1 OCA].
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[[Category: Mycolicibacterium fortuitum]]
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[[Category: Charlier P]]
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==Reference==
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[[Category: Fonze E]]
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<ref group="xtra">PMID:16801434</ref><references group="xtra"/>
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[[Category: Sauvage E]]
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[[Category: Beta-lactamase]]
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[[Category: Charlier, P.]]
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[[Category: Fonze, E.]]
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[[Category: Sauvage, E.]]
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[[Category: Antibiotic resistance]]
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[[Category: Beta-lactamase]]
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[[Category: Broad-spectrum]]
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[[Category: Hydrolase]]
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[[Category: Penicillin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 08:38:55 2009''
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Current revision

Crystal structure of the class A beta-lactamase from Mycobacterium fortuitum

PDB ID 2cc1

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