2rq5
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 2rq5 is ON HOLD Authors: Kusunoki, H., Takeuchi, T., Kohno, T. Description: Solution structure of the AT-rich interaction domain (ARID) of Jumonji/...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Solution structure of the AT-rich interaction domain (ARID) of Jumonji/JARID2== | |
| - | + | <StructureSection load='2rq5' size='340' side='right'caption='[[2rq5]]' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[2rq5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RQ5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RQ5 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rq5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rq5 OCA], [https://pdbe.org/2rq5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rq5 RCSB], [https://www.ebi.ac.uk/pdbsum/2rq5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rq5 ProSAT]</span></td></tr> | |
| - | '' | + | </table> |
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/JARD2_MOUSE JARD2_MOUSE] Regulator of histone methyltransferase complexes that plays an essential role in embryonic development, including heart and liver development, neural tube fusion process and hematopoiesis. Acts by modulating histone methyltransferase activity and promoting the recruitment of histone methyltransferase complexes to their target genes. Binds DNA and mediates the recruitment of the PRC2 complex to target genes in embryonic stem cells. Does not have histone demethylase activity but regulates activity of various histone methyltransferase complexes. In embryonic stem cells, it associates with the PRC2 complex and inhibits trimethylation of 'Lys-27' of histone H3 (H3K27me3) by the PRC2 complex, thereby playing a key role in differentiation of embryonic stem cells and normal development. In cardiac cells, it is required to repress expression of cyclin-D1 (CCND1) by activating methylation of 'Lys-9' of histone H3 (H3K9me) by the GLP1/EHMT1 and G9a/EHMT2 histone methyltransferases. Also acts as a transcriptional repressor of ANF via its interaction with GATA4 and NKX2-5. Participates in the negative regulation of cell proliferation signaling.<ref>PMID:10913339</ref> <ref>PMID:10807864</ref> <ref>PMID:12852854</ref> <ref>PMID:12890668</ref> <ref>PMID:15542826</ref> <ref>PMID:15870077</ref> <ref>PMID:20064376</ref> <ref>PMID:20064375</ref> <ref>PMID:19010785</ref> <ref>PMID:20075857</ref> | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rq/2rq5_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2rq5 ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Mus musculus]] | ||
| + | [[Category: Kohno T]] | ||
| + | [[Category: Kusunoki H]] | ||
Current revision
Solution structure of the AT-rich interaction domain (ARID) of Jumonji/JARID2
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