3bti

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{{Seed}}
 
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[[Image:3bti.png|left|200px]]
 
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==crystal structure of QacR(E58Q) bound to berberine==
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The line below this paragraph, containing "STRUCTURE_3bti", creates the "Structure Box" on the page.
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<StructureSection load='3bti' size='340' side='right'caption='[[3bti]], [[Resolution|resolution]] 2.85&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3bti]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_Mu50 Staphylococcus aureus subsp. aureus Mu50]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BTI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3BTI FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.85&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BER:BERBERINE'>BER</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_3bti| PDB=3bti | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3bti FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bti OCA], [https://pdbe.org/3bti PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3bti RCSB], [https://www.ebi.ac.uk/pdbsum/3bti PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3bti ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/QACR_STAAM QACR_STAAM] Transcriptional repressor of qacA. Binds to IR1, an unusually long 28 bp operator, which is located downstream from the qacA promoter and overlaps its transcription start site. QacR is induced from its IR1 site by binding to one of many structurally dissimilar cationic lipophilic compounds, which are also substrates of QacA (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bt/3bti_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3bti ConSurf].
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<div style="clear:both"></div>
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===crystal structure of QacR(E58Q) bound to berberine===
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==See Also==
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*[[Tetracycline repressor protein 3D structures|Tetracycline repressor protein 3D structures]]
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*[[Transcriptional activator 3D structures|Transcriptional activator 3D structures]]
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__TOC__
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The line below this paragraph, {{ABSTRACT_PUBMED_18616285}}, adds the Publication Abstract to the page
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</StructureSection>
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(as it appears on PubMed at http://www.pubmed.gov), where 18616285 is the PubMed ID number.
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[[Category: Large Structures]]
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[[Category: Staphylococcus aureus subsp. aureus Mu50]]
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{{ABSTRACT_PUBMED_18616285}}
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[[Category: Brennan RG]]
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[[Category: Schumacher MA]]
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==About this Structure==
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[[Category: Schuman JT]]
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3BTI is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BTI OCA].
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==Reference==
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<ref group="xtra">PMID:18616285</ref><references group="xtra"/>
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[[Category: Staphylococcus aureus]]
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[[Category: Brennan, R G.]]
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[[Category: Schumacher, M A.]]
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[[Category: Schuman, J T.]]
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[[Category: Berberine]]
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[[Category: Dna-binding]]
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[[Category: Multidrug binding]]
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[[Category: Natural drug]]
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[[Category: Plasmid]]
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[[Category: Qacr]]
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[[Category: Repressor]]
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[[Category: Transcription]]
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[[Category: Transcription regulation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 08:52:34 2009''
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Current revision

crystal structure of QacR(E58Q) bound to berberine

PDB ID 3bti

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