1hrp

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{{Seed}}
 
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[[Image:1hrp.png|left|200px]]
 
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==CRYSTAL STRUCTURE OF HUMAN CHORIONIC GONADOTROPIN==
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The line below this paragraph, containing "STRUCTURE_1hrp", creates the "Structure Box" on the page.
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<StructureSection load='1hrp' size='340' side='right'caption='[[1hrp]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1hrp]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HRP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HRP FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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{{STRUCTURE_1hrp| PDB=1hrp | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1hrp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hrp OCA], [https://pdbe.org/1hrp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1hrp RCSB], [https://www.ebi.ac.uk/pdbsum/1hrp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1hrp ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CGB3_HUMAN CGB3_HUMAN]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hr/1hrp_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1hrp ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The three-dimensional structure of human chorionic gonadotropin shows that each of its two different subunits has a similar topology, with three disulphide bonds forming a cystine knot. This same folding motif is found in some protein growth factors. The heterodimer is stabilized by a segment of the beta-subunit which wraps around the alpha-subunit and is covalently linked like a seat belt by the disulphide Cys 26-Cys 110. This extraordinary feature appears to be essential not only for the association of these heterodimers but also for receptor binding by the glycoprotein hormones.
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===CRYSTAL STRUCTURE OF HUMAN CHORIONIC GONADOTROPIN===
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Crystal structure of human chorionic gonadotropin.,Lapthorn AJ, Harris DC, Littlejohn A, Lustbader JW, Canfield RE, Machin KJ, Morgan FJ, Isaacs NW Nature. 1994 Jun 9;369(6480):455-61. PMID:8202136<ref>PMID:8202136</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 1hrp" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_8202136}}, adds the Publication Abstract to the page
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*[[Hormone|Hormone]]
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(as it appears on PubMed at http://www.pubmed.gov), where 8202136 is the PubMed ID number.
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*[[Human Follicle-Stimulating Hormone Complexed with its Receptor|Human Follicle-Stimulating Hormone Complexed with its Receptor]]
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== References ==
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{{ABSTRACT_PUBMED_8202136}}
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<references/>
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__TOC__
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==About this Structure==
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</StructureSection>
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1HRP is a 2 chains structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HRP OCA].
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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==Reference==
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[[Category: Harris DC]]
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<ref group="xtra">PMID:8202136</ref><references group="xtra"/>
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[[Category: Isaacs NW]]
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[[Category: Harris, D C.]]
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[[Category: Lapthorn AJ]]
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[[Category: Isaacs, N W.]]
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[[Category: Lapthorn, A J.]]
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[[Category: Hormone]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 08:54:38 2009''
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Current revision

CRYSTAL STRUCTURE OF HUMAN CHORIONIC GONADOTROPIN

PDB ID 1hrp

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