3eox

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (15:22, 1 November 2023) (edit) (undo)
 
(8 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:3eox.jpg|left|200px]]
 
-
<!--
+
==High quality structure of cleaved PAI-1-stab==
-
The line below this paragraph, containing "STRUCTURE_3eox", creates the "Structure Box" on the page.
+
<StructureSection load='3eox' size='340' side='right'caption='[[3eox]], [[Resolution|resolution]] 2.61&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[3eox]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EOX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3EOX FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.61&#8491;</td></tr>
-
-->
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3eox FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3eox OCA], [https://pdbe.org/3eox PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3eox RCSB], [https://www.ebi.ac.uk/pdbsum/3eox PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3eox ProSAT]</span></td></tr>
-
{{STRUCTURE_3eox| PDB=3eox | SCENE= }}
+
</table>
 +
== Disease ==
 +
[https://www.uniprot.org/uniprot/PAI1_HUMAN PAI1_HUMAN] Defects in SERPINE1 are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1D) [MIM:[https://omim.org/entry/613329 613329]. It is a hematologic disorder characterized by increased bleeding after trauma, injury, or surgery. Affected females have menorrhagia. The bleeding defect is due to increased fibrinolysis of fibrin blood clots due to deficiency of plasminogen activator inhibitor-1, which inhibits tissue and urinary activators of plasminogen.<ref>PMID:9207454</ref> Note=High concentrations of SERPINE1 seem to contribute to the development of venous but not arterial occlusions.
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/PAI1_HUMAN PAI1_HUMAN] Serine protease inhibitor. This inhibitor acts as 'bait' for tissue plasminogen activator, urokinase, protein C and matriptase-3/TMPRSS7. Its rapid interaction with PLAT may function as a major control point in the regulation of fibrinolysis.<ref>PMID:15853774</ref>
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/eo/3eox_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3eox ConSurf].
 +
<div style="clear:both"></div>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
Here we report the crystal structure of a stablilized plasminogen activator inhibitor-1 variant (PAI-1-N150H-K154T-Q301P-Q319L-M354I (PAI-1-stab)) that shows a cleavage within the reactive centre loop. The new structure is of superior quality compared to the previously determined structure of the cleaved PAI-1-A335P mutant. We present a detailed comparison of the two structures and also compare them with the structure of the active PAI-1-stab. The structural data give important insights into the working mechanism of PAI-1 and also explain the role of various stabilizing mutations.
-
===High quality structure of cleaved PAI-1-stab===
+
High quality structure of cleaved PAI-1-stab.,Dewilde M, Strelkov SV, Rabijns A, Declerck PJ J Struct Biol. 2009 Feb;165(2):126-32. Epub 2008 Nov 27. PMID:19059484<ref>PMID:19059484</ref>
 +
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 +
</div>
 +
<div class="pdbe-citations 3eox" style="background-color:#fffaf0;"></div>
-
<!--
+
==See Also==
-
The line below this paragraph, {{ABSTRACT_PUBMED_19059484}}, adds the Publication Abstract to the page
+
*[[Plasminogen activator inhibitor|Plasminogen activator inhibitor]]
-
(as it appears on PubMed at http://www.pubmed.gov), where 19059484 is the PubMed ID number.
+
== References ==
-
-->
+
<references/>
-
{{ABSTRACT_PUBMED_19059484}}
+
__TOC__
-
 
+
</StructureSection>
-
==About this Structure==
+
-
3EOX is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EOX OCA].
+
-
 
+
-
==Reference==
+
-
<ref group="xtra">PMID:19059484</ref><references group="xtra"/>
+
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Declerck, P J.]]
+
[[Category: Large Structures]]
-
[[Category: Dewilde, M.]]
+
[[Category: Declerck PJ]]
-
[[Category: Rabijns, A.]]
+
[[Category: Dewilde M]]
-
[[Category: Strelkov, S V.]]
+
[[Category: Rabijns A]]
-
[[Category: Blood clotting]]
+
[[Category: Strelkov SV]]
-
[[Category: Cleaved plasminogen activator inhibitor-1]]
+
-
[[Category: Glycoprotein]]
+
-
[[Category: Pai-1]]
+
-
[[Category: Plasminogen activation]]
+
-
[[Category: Polymorphism]]
+
-
[[Category: Protease inhibitor]]
+
-
[[Category: Secreted]]
+
-
[[Category: Serine protease inhibitor]]
+
-
[[Category: Serpin]]
+
-
[[Category: Stabilized]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 09:03:38 2009''
+

Current revision

High quality structure of cleaved PAI-1-stab

PDB ID 3eox

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3eox"
Personal tools