3cxp

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{{Seed}}
 
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[[Image:3cxp.png|left|200px]]
 
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==Crystal structure of human glucosamine 6-phosphate N-acetyltransferase 1 mutant E156A==
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The line below this paragraph, containing "STRUCTURE_3cxp", creates the "Structure Box" on the page.
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<StructureSection load='3cxp' size='340' side='right'caption='[[3cxp]], [[Resolution|resolution]] 2.01&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3cxp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CXP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CXP FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.01&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
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{{STRUCTURE_3cxp| PDB=3cxp | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3cxp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cxp OCA], [https://pdbe.org/3cxp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3cxp RCSB], [https://www.ebi.ac.uk/pdbsum/3cxp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3cxp ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/GNA1_HUMAN GNA1_HUMAN]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cx/3cxp_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3cxp ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Glucosamine-6-phosphate (GlcN6P) N-acetyltransferase 1 (GNA1) is a key enzyme in the pathway toward biosynthesis of UDP-N-acetylglucosamine, an important donor substrate for N-linked glycosylation. GNA1 catalyzes the formation of N-acetylglucosamine-6-phosphate (GlcNAc6P) from acetyl-CoA (AcCoA) and the acceptor substrate GlcN6P. Here, we report crystal structures of human GNA1, including apo GNA1, the GNA1-GlcN6P complex and an E156A mutant. Our work showed that GlcN6P binds to GNA1 without the help of AcCoA binding. Structural analyses and mutagenesis studies have shed lights on the charge distribution in the GlcN6P binding pocket, and an important role for Glu156 in the substrate binding. Hence, these findings have broadened our knowledge of structural features required for the substrate affinity of GNA1.
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===Crystal structure of human glucosamine 6-phosphate N-acetyltransferase 1 mutant E156A===
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Acceptor substrate binding revealed by crystal structure of human glucosamine-6-phosphate N-acetyltransferase 1.,Wang J, Liu X, Liang YH, Li LF, Su XD FEBS Lett. 2008 Sep 3;582(20):2973-8. Epub 2008 Aug 7. PMID:18675810<ref>PMID:18675810</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_18675810}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 3cxp" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 18675810 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_18675810}}
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__TOC__
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</StructureSection>
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==About this Structure==
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3CXP is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CXP OCA].
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==Reference==
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<ref group="xtra">PMID:18675810</ref><references group="xtra"/>
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[[Category: Glucosamine 6-phosphate N-acetyltransferase]]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Li, L F.]]
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[[Category: Large Structures]]
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[[Category: Liu, X.]]
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[[Category: Li L-F]]
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[[Category: Su, X D.]]
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[[Category: Liu X]]
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[[Category: Wang, J.]]
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[[Category: Su X-D]]
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[[Category: Acyltransferase]]
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[[Category: Wang J]]
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[[Category: Endosome]]
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[[Category: Gna1]]
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[[Category: Golgi apparatus]]
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[[Category: Membrane]]
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[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 09:05:58 2009''
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Current revision

Crystal structure of human glucosamine 6-phosphate N-acetyltransferase 1 mutant E156A

PDB ID 3cxp

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OCA

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