1xfu

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{{Seed}}
 
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[[Image:1xfu.png|left|200px]]
 
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==Crystal structure of anthrax edema factor (EF) truncation mutant, EF-delta 64 in complex with calmodulin==
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The line below this paragraph, containing "STRUCTURE_1xfu", creates the "Structure Box" on the page.
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<StructureSection load='1xfu' size='340' side='right'caption='[[1xfu]], [[Resolution|resolution]] 3.35&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1xfu]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_anthracis Bacillus anthracis] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XFU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XFU FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.35&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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{{STRUCTURE_1xfu| PDB=1xfu | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xfu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xfu OCA], [https://pdbe.org/1xfu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xfu RCSB], [https://www.ebi.ac.uk/pdbsum/1xfu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xfu ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CYAA_BACAN CYAA_BACAN] One of the three proteins composing the anthrax toxin, the agent which infects many mammalian species and that may cause death. EF is a calmodulin-dependent adenylyl cyclase that, when associated with PA, causes edema. EF is not toxic by itself and it is required for the survival of germinated spores within macrophages at the early stages of infection. Provokes dramatic elevation of intracellular cAMP levels in the host.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xf/1xfu_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1xfu ConSurf].
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<div style="clear:both"></div>
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===Crystal structure of anthrax edema factor (EF) truncation mutant, EF-delta 64 in complex with calmodulin===
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==See Also==
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*[[Anthrax edema factor 3D structures|Anthrax edema factor 3D structures]]
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*[[Calmodulin 3D structures|Calmodulin 3D structures]]
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__TOC__
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</StructureSection>
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(as it appears on PubMed at http://www.pubmed.gov), where 15719022 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15719022}}
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==About this Structure==
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1XFU is a 12 chains structure of sequences from [http://en.wikipedia.org/wiki/Bacillus_anthracis Bacillus anthracis] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XFU OCA].
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==Reference==
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<ref group="xtra">PMID:15719022</ref><references group="xtra"/>
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[[Category: Adenylate cyclase]]
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[[Category: Bacillus anthracis]]
[[Category: Bacillus anthracis]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Florian, J.]]
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[[Category: Large Structures]]
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[[Category: Guo, Q.]]
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[[Category: Florian J]]
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[[Category: Shen, Y.]]
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[[Category: Guo Q]]
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[[Category: Tang, W J.]]
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[[Category: Shen Y]]
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[[Category: Zhukovskaya, N L.]]
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[[Category: Tang WJ]]
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[[Category: Protein-protein complex]]
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[[Category: Zhukovskaya NL]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 09:09:21 2009''
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Current revision

Crystal structure of anthrax edema factor (EF) truncation mutant, EF-delta 64 in complex with calmodulin

PDB ID 1xfu

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