2gdc

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{{Seed}}
 
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[[Image:2gdc.png|left|200px]]
 
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==Structure of Vinculin VD1 / IpaA560-633 complex==
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The line below this paragraph, containing "STRUCTURE_2gdc", creates the "Structure Box" on the page.
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<StructureSection load='2gdc' size='340' side='right'caption='[[2gdc]], [[Resolution|resolution]] 2.74&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2gdc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus] and [https://en.wikipedia.org/wiki/Shigella_flexneri Shigella flexneri]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GDC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GDC FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.74&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2gdc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gdc OCA], [https://pdbe.org/2gdc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2gdc RCSB], [https://www.ebi.ac.uk/pdbsum/2gdc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2gdc ProSAT]</span></td></tr>
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{{STRUCTURE_2gdc| PDB=2gdc | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/VINC_CHICK VINC_CHICK] Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell-surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion.<ref>PMID:15229287</ref> <ref>PMID:20584916</ref> <ref>PMID:20086044</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gd/2gdc_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2gdc ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Invasion of epithelial cells by Shigella flexneri is characterized by cytoskeletal rearrangements of the host cell membrane, promoting internalization of the bacterium. The bacterial effector IpaA is injected into the epithelial cell by a type III secretion apparatus and recruits vinculin to regulate actin polymerization at the site of entry. We analysed the complex formed between a carboxy-terminal fragment of IpaA (IpaA(560-633)) and the vinculin D1 domain (VD1), both in crystals and in solution. We present evidence that IpaA(560-633) has two alpha-helical vinculin-binding sites that simultaneously bind two VD1 molecules. The interaction of IpaA(560-633) with VD1 is highly similar to the interaction of the endogenous, eukaryotic proteins talin and alpha-actinin with VD1, showing that Shigella uses a structural mimicry strategy to activate vinculin.
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===Structure of Vinculin VD1 / IpaA560-633 complex===
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Structural mimicry for vinculin activation by IpaA, a virulence factor of Shigella flexneri.,Hamiaux C, van Eerde A, Parsot C, Broos J, Dijkstra BW EMBO Rep. 2006 Aug;7(8):794-9. Epub 2006 Jul 7. PMID:16826238<ref>PMID:16826238</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2gdc" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_16826238}}, adds the Publication Abstract to the page
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*[[Vinculin|Vinculin]]
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(as it appears on PubMed at http://www.pubmed.gov), where 16826238 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_16826238}}
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__TOC__
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</StructureSection>
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==About this Structure==
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2GDC is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus] and [http://en.wikipedia.org/wiki/Shigella_flexneri Shigella flexneri]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GDC OCA].
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==Reference==
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<ref group="xtra">PMID:16826238</ref><references group="xtra"/>
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[[Category: Gallus gallus]]
[[Category: Gallus gallus]]
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[[Category: Large Structures]]
[[Category: Shigella flexneri]]
[[Category: Shigella flexneri]]
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[[Category: Broos, J.]]
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[[Category: Broos J]]
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[[Category: Dijkstra, B W.]]
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[[Category: Dijkstra BW]]
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[[Category: Eerde, A van.]]
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[[Category: Hamiaux C]]
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[[Category: Hamiaux, C.]]
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[[Category: Parsot C]]
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[[Category: Parsot, C.]]
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[[Category: Van Eerde A]]
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[[Category: Helical bundle conversion]]
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[[Category: Ipaa/vinculin complex]]
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[[Category: Shigella flexneri]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 09:09:58 2009''
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Current revision

Structure of Vinculin VD1 / IpaA560-633 complex

PDB ID 2gdc

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