1ztm

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{{Seed}}
 
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[[Image:1ztm.png|left|200px]]
 
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==Structure of the Uncleaved Paramyxovirus (hPIV3) Fusion Protein==
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The line below this paragraph, containing "STRUCTURE_1ztm", creates the "Structure Box" on the page.
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<StructureSection load='1ztm' size='340' side='right'caption='[[1ztm]], [[Resolution|resolution]] 3.05&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZTM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZTM FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.05&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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{{STRUCTURE_1ztm| PDB=1ztm | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ztm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ztm OCA], [https://pdbe.org/1ztm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ztm RCSB], [https://www.ebi.ac.uk/pdbsum/1ztm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ztm ProSAT]</span></td></tr>
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</table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zt/1ztm_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ztm ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Class I viral fusion proteins share common mechanistic and structural features but little sequence similarity. Structural insights into the protein conformational changes associated with membrane fusion are based largely on studies of the influenza virus hemagglutinin in pre- and postfusion conformations. Here, we present the crystal structure of the secreted, uncleaved ectodomain of the paramyxovirus, human parainfluenza virus 3 fusion (F) protein, a member of the class I viral fusion protein group. The secreted human parainfluenza virus 3 F forms a trimer with distinct head, neck, and stalk regions. Unexpectedly, the structure reveals a six-helix bundle associated with the postfusion form of F, suggesting that the anchor-minus ectodomain adopts a conformation largely similar to the postfusion state. The transmembrane anchor domains of F may therefore profoundly influence the folding energetics that establish and maintain a metastable, prefusion state.
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===Structure of the Uncleaved Paramyxovirus (hPIV3) Fusion Protein===
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Structure of the uncleaved ectodomain of the paramyxovirus (hPIV3) fusion protein.,Yin HS, Paterson RG, Wen X, Lamb RA, Jardetzky TS Proc Natl Acad Sci U S A. 2005 Jun 28;102(26):9288-93. Epub 2005 Jun 17. PMID:15964978<ref>PMID:15964978</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_15964978}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1ztm" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 15964978 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_15964978}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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1ZTM is a 3 chains structure of sequences from [http://en.wikipedia.org/wiki/Human_parainfluenza_virus_3 Human parainfluenza virus 3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZTM OCA].
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[[Category: Jardetzky TS]]
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[[Category: Lamb RA]]
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==Reference==
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[[Category: Paterson RG]]
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<ref group="xtra">PMID:15964978</ref><references group="xtra"/>
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[[Category: Wen X]]
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[[Category: Human parainfluenza virus 3]]
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[[Category: Yin HS]]
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[[Category: Jardetzky, T S.]]
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[[Category: Lamb, R A.]]
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[[Category: Paterson, R G.]]
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[[Category: Wen, X.]]
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[[Category: Yin, H S.]]
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[[Category: 6-helix bundle,trimer]]
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[[Category: Fusion protein]]
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[[Category: Post-fusion]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 09:18:03 2009''
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Current revision

Structure of the Uncleaved Paramyxovirus (hPIV3) Fusion Protein

PDB ID 1ztm

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