2jy7

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{{Seed}}
 
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[[Image:2jy7.png|left|200px]]
 
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==NMR structure of the ubiquitin associated (UBA) domain of p62 (SQSTM1). RDC refined==
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The line below this paragraph, containing "STRUCTURE_2jy7", creates the "Structure Box" on the page.
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<StructureSection load='2jy7' size='340' side='right'caption='[[2jy7]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2jy7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JY7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JY7 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jy7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jy7 OCA], [https://pdbe.org/2jy7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jy7 RCSB], [https://www.ebi.ac.uk/pdbsum/2jy7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jy7 ProSAT]</span></td></tr>
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{{STRUCTURE_2jy7| PDB=2jy7 | SCENE= }}
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/SQSTM_HUMAN SQSTM_HUMAN] Defects in SQSTM1 are a cause of Paget disease of bone (PDB) [MIM:[https://omim.org/entry/602080 602080]. PDB is a metabolic bone disease affecting the axial skeleton and characterized by focal areas of increased and disorganized bone turn-over due to activated osteoclasts. Manifestations of the disease include bone pain, deformity, pathological fractures, deafness, neurological complications and increased risk of osteosarcoma. PDB is a chronic disease affecting 2 to 3% of the population above the age of 40 years.<ref>PMID:19931284</ref> <ref>PMID:11992264</ref> <ref>PMID:12374763</ref> <ref>PMID:14584883</ref> <ref>PMID:15146436</ref> <ref>PMID:15207768</ref> <ref>PMID:15125799</ref> <ref>PMID:15176995</ref> Note=In a cell model for Huntington disease (HD), appears to form a shell surrounding aggregates of mutant HTT that may protect cells from apoptosis, possibly by recruiting autophagosomal components to the polyubiquitinylated protein aggregates.<ref>PMID:16286508</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/SQSTM_HUMAN SQSTM_HUMAN] Required both for the formation and autophagic degradation of polyubiquitin-containing bodies, called ALIS (aggresome-like induced structures). Links ALIS to the autophagic machinery via direct interaction with MAP1 LC3 family members. May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1. May play a role in titin/TTN downstream signaling in muscle cells. May regulate signaling cascades through ubiquitination. Adapter that mediates the interaction between TRAF6 and CYLD (By similarity). May be involved in cell differentiation, apoptosis, immune response and regulation of K(+) channels.<ref>PMID:10356400</ref> <ref>PMID:10747026</ref> <ref>PMID:11244088</ref> <ref>PMID:12471037</ref> <ref>PMID:15340068</ref> <ref>PMID:16079148</ref> <ref>PMID:16286508</ref> <ref>PMID:15953362</ref> <ref>PMID:15911346</ref> <ref>PMID:15802564</ref> <ref>PMID:19931284</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jy/2jy7_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jy7 ConSurf].
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<div style="clear:both"></div>
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===NMR structure of the ubiquitin associated (UBA) domain of p62 (SQSTM1). RDC refined===
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==See Also==
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*[[Sequestosome|Sequestosome]]
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== References ==
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The line below this paragraph, {{ABSTRACT_PUBMED_18083707}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 18083707 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_18083707}}
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==About this Structure==
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2JY7 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JY7 OCA].
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==Reference==
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<ref group="xtra">PMID:18083707</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Layfield, R.]]
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[[Category: Large Structures]]
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[[Category: Long, J E.]]
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[[Category: Layfield R]]
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[[Category: Searle, M S.]]
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[[Category: Long JE]]
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[[Category: Alternative splicing]]
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[[Category: Searle MS]]
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[[Category: Apoptosis]]
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[[Category: Cytoplasm]]
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[[Category: Differentiation]]
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[[Category: Disease mutation]]
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[[Category: Endosome]]
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[[Category: Helical bundle]]
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[[Category: Immune response]]
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[[Category: Metal-binding]]
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[[Category: Nucleus]]
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[[Category: Phosphoprotein]]
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[[Category: Polymorphism]]
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[[Category: Protein binding]]
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[[Category: Three helice]]
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[[Category: Ubiquitin associated domain]]
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[[Category: Ubiquitin binding]]
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[[Category: Zinc]]
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[[Category: Zinc-finger]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 09:19:11 2009''
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Current revision

NMR structure of the ubiquitin associated (UBA) domain of p62 (SQSTM1). RDC refined

PDB ID 2jy7

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OCA

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