2c7a

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{{Seed}}
 
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[[Image:2c7a.png|left|200px]]
 
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==STRUCTURE OF THE PROGESTERONE RECEPTOR-DNA COMPLEX==
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The line below this paragraph, containing "STRUCTURE_2c7a", creates the "Structure Box" on the page.
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<StructureSection load='2c7a' size='340' side='right'caption='[[2c7a]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2c7a]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C7A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2C7A FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_2c7a| PDB=2c7a | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2c7a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c7a OCA], [https://pdbe.org/2c7a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2c7a RCSB], [https://www.ebi.ac.uk/pdbsum/2c7a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2c7a ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PRGR_HUMAN PRGR_HUMAN] The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Progesterone receptor isoform B (PRB) is involved activation of c-SRC/MAPK signaling on hormone stimulation.<ref>PMID:15572662</ref> <ref>PMID:15798179</ref> <ref>PMID:17020914</ref> <ref>PMID:17347654</ref> <ref>PMID:17717077</ref> <ref>PMID:17173941</ref> <ref>PMID:18202149</ref> Isoform A is inactive in stimulating c-Src/MAPK signaling on hormone stimulation.<ref>PMID:15572662</ref> <ref>PMID:15798179</ref> <ref>PMID:17020914</ref> <ref>PMID:17347654</ref> <ref>PMID:17717077</ref> <ref>PMID:17173941</ref> <ref>PMID:18202149</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c7/2c7a_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2c7a ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The DNA binding domain (DBD) of nuclear hormone receptors contains a highly conserved globular domain and a less conserved carboxyl-terminal extension (CTE). Despite previous observations that the CTEs of some classes of nuclear receptors are structured and interact with DNA outside of the hexanucleotide hormone response element (HRE), there has been no evidence for such a CTE among the steroid receptors. We have determined the structure of the progesterone receptor (PR)-DBD-CTE DNA complex at a resolution of 2.5 A, which revealed binding of the CTE to the minor groove flanking the HREs. Alanine substitutions of the interacting CTE residues reduced affinity for inverted repeat HREs separated by three nucleotides, and essentially abrogated binding to a single HRE. A highly compressed minor groove of the trinucleotide spacer and a novel dimerization interface were also observed. A PR binding site selection experiment revealed sequence preferences in the trinucleotide spacer and flanking DNA. These results, taken together, support the notion that sequences outside of the HREs influence the DNA binding affinity and specificity of steroid receptors.
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===STRUCTURE OF THE PROGESTERONE RECEPTOR-DNA COMPLEX===
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Structure of the progesterone receptor-deoxyribonucleic acid complex: novel interactions required for binding to half-site response elements.,Roemer SC, Donham DC, Sherman L, Pon VH, Edwards DP, Churchill ME Mol Endocrinol. 2006 Dec;20(12):3042-52. Epub 2006 Aug 24. PMID:16931575<ref>PMID:16931575</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2c7a" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_16931575}}, adds the Publication Abstract to the page
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*[[Progesterone receptor|Progesterone receptor]]
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(as it appears on PubMed at http://www.pubmed.gov), where 16931575 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_16931575}}
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__TOC__
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</StructureSection>
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==About this Structure==
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2C7A is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C7A OCA].
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==Reference==
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<ref group="xtra">PMID:16931575</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Churchill, M E.A.]]
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[[Category: Large Structures]]
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[[Category: Donham, D C.]]
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[[Category: Churchill MEA]]
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[[Category: Edwards, D P.]]
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[[Category: Donham DC]]
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[[Category: Pon, V H.]]
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[[Category: Edwards DP]]
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[[Category: Roemer, S C.]]
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[[Category: Pon VH]]
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[[Category: Sherman, L.]]
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[[Category: Roemer SC]]
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[[Category: Complex]]
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[[Category: Sherman L]]
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[[Category: Dna-binding]]
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[[Category: Metal-binding]]
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[[Category: Nuclear protein]]
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[[Category: Phosphorylation]]
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[[Category: Progesterone receptor]]
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[[Category: Receptor/dna complex]]
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[[Category: Steroid-binding]]
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[[Category: Transcription regulation]]
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[[Category: Zinc]]
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[[Category: Zinc-finger]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 09:22:55 2009''
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Current revision

STRUCTURE OF THE PROGESTERONE RECEPTOR-DNA COMPLEX

PDB ID 2c7a

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