1mja

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{{Seed}}
 
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[[Image:1mja.png|left|200px]]
 
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==Crystal structure of yeast Esa1 histone acetyltransferase domain complexed with acetyl coenzyme A==
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The line below this paragraph, containing "STRUCTURE_1mja", creates the "Structure Box" on the page.
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<StructureSection load='1mja' size='340' side='right'caption='[[1mja]], [[Resolution|resolution]] 2.26&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1mja]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MJA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MJA FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.26&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=COA:COENZYME+A'>COA</scene>, <scene name='pdbligand=SCY:S-ACETYL-CYSTEINE'>SCY</scene></td></tr>
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{{STRUCTURE_1mja| PDB=1mja | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1mja FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mja OCA], [https://pdbe.org/1mja PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1mja RCSB], [https://www.ebi.ac.uk/pdbsum/1mja PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1mja ProSAT]</span></td></tr>
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</table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mj/1mja_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1mja ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Yeast ESA1 is a member of the MYST subfamily of histone acetyltransferases (HATs), which use acetyl-coenzyme A (CoA) to acetylate specific Lys residues within histones to regulate gene expression. The structure of an ESA1-CoA complex reveals structural similarity to the catalytic core of the GCN5/PCAF subfamily of HAT proteins. Here we report additional structural and functional studies on ESA1 that demonstrate that histone acetylation proceeds through an acetyl-cysteine enzyme intermediate. This Cys residue is strictly conserved within the MYST members, suggesting a common mode of catalysis by this HAT subfamily. However, this mode of catalysis differs dramatically from the GCN5/PCAF subfamily, which mediate direct nucleophilic attack of the acetyl-CoA cofactor by the enzyme-deprotonated substrate lysine of the histone. These results demonstrate that different HAT subfamilies can use distinct catalytic mechanisms, which have implications for their distinct biological roles and for the development of HAT-specific inhibitors.
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===Crystal structure of yeast Esa1 histone acetyltransferase domain complexed with acetyl coenzyme A===
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The catalytic mechanism of the ESA1 histone acetyltransferase involves a self-acetylated intermediate.,Yan Y, Harper S, Speicher DW, Marmorstein R Nat Struct Biol. 2002 Nov;9(11):862-9. PMID:12368900<ref>PMID:12368900</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 1mja" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_12368900}}, adds the Publication Abstract to the page
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*[[Histone acetyltransferase 3D structures|Histone acetyltransferase 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 12368900 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_12368900}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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1MJA is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MJA OCA].
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==Reference==
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<ref group="xtra">PMID:12368900</ref><references group="xtra"/>
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[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
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[[Category: Harper, S.]]
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[[Category: Harper S]]
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[[Category: Marmorstein, R.]]
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[[Category: Marmorstein R]]
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[[Category: Speicher, D.]]
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[[Category: Speicher D]]
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[[Category: Yan, Y.]]
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[[Category: Yan Y]]
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[[Category: Esa1]]
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[[Category: Hat]]
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[[Category: Histone acetyltransferase]]
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[[Category: Myst]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 09:27:03 2009''
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Current revision

Crystal structure of yeast Esa1 histone acetyltransferase domain complexed with acetyl coenzyme A

PDB ID 1mja

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