1ls6

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{{Seed}}
 
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[[Image:1ls6.png|left|200px]]
 
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==Human SULT1A1 complexed with PAP and p-Nitrophenol==
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The line below this paragraph, containing "STRUCTURE_1ls6", creates the "Structure Box" on the page.
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<StructureSection load='1ls6' size='340' side='right'caption='[[1ls6]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1ls6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LS6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1LS6 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A3P:ADENOSINE-3-5-DIPHOSPHATE'>A3P</scene>, <scene name='pdbligand=NPO:P-NITROPHENOL'>NPO</scene></td></tr>
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{{STRUCTURE_1ls6| PDB=1ls6 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ls6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ls6 OCA], [https://pdbe.org/1ls6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ls6 RCSB], [https://www.ebi.ac.uk/pdbsum/1ls6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ls6 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ST1A1_HUMAN ST1A1_HUMAN] Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of catecholamines, phenolic drugs and neurotransmitters. Has also estrogen sulfotransferase activity. responsible for the sulfonation and activation of minoxidil. Is Mediates the metabolic activation of carcinogenic N-hydroxyarylamines to DNA binding products and could so participate as modulating factor of cancer risk.<ref>PMID:12471039</ref> <ref>PMID:16221673</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ls/1ls6_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ls6 ConSurf].
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<div style="clear:both"></div>
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===Human SULT1A1 complexed with PAP and p-Nitrophenol===
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==See Also==
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*[[Sulfotransferase 3D structures|Sulfotransferase 3D structures]]
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_12471039}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 12471039 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_12471039}}
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==About this Structure==
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1LS6 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LS6 OCA].
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==Reference==
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<ref group="xtra">PMID:12471039</ref><references group="xtra"/>
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[[Category: Aryl sulfotransferase]]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Barnett, A C.]]
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[[Category: Large Structures]]
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[[Category: Gamage, N U.]]
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[[Category: Barnett AC]]
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[[Category: Latham, C F.]]
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[[Category: Gamage NU]]
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[[Category: Liyou, N E.]]
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[[Category: Latham CF]]
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[[Category: Martin, J L.]]
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[[Category: Liyou NE]]
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[[Category: McManus, M E.]]
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[[Category: Martin JL]]
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[[Category: Tresillian, M.]]
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[[Category: McManus ME]]
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[[Category: P-nitrophenol]]
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[[Category: Tresillian M]]
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[[Category: Pap]]
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[[Category: Positive cooperativity]]
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[[Category: Sult 1a1]]
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[[Category: Two substrate binding site]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 09:28:10 2009''
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Current revision

Human SULT1A1 complexed with PAP and p-Nitrophenol

PDB ID 1ls6

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