1j1j

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{{Seed}}
 
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[[Image:1j1j.png|left|200px]]
 
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==Crystal Structure of human Translin==
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The line below this paragraph, containing "STRUCTURE_1j1j", creates the "Structure Box" on the page.
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<StructureSection load='1j1j' size='340' side='right'caption='[[1j1j]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1j1j]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1J1J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1J1J FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1j1j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1j1j OCA], [https://pdbe.org/1j1j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1j1j RCSB], [https://www.ebi.ac.uk/pdbsum/1j1j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1j1j ProSAT]</span></td></tr>
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{{STRUCTURE_1j1j| PDB=1j1j | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TSN_HUMAN TSN_HUMAN] DNA-binding protein that specifically recognizes consensus sequences at the breakpoint junctions in chromosomal translocations, mostly involving immunoglobulin (Ig)/T-cell receptor gene segments. Seems to recognize single-stranded DNA ends generated by staggered breaks occurring at recombination hot spots.<ref>PMID:9111049</ref> <ref>PMID:21552258</ref> Exhibits both single-stranded and double-stranded endoribonuclease activity. May act as an activator of RNA-induced silencing complex (RISC) by facilitating endonucleolytic cleavage of the siRNA passenger strand.<ref>PMID:9111049</ref> <ref>PMID:21552258</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/j1/1j1j_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1j1j ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The structure of human translin at 2.2 A resolution is reported in space group C222(1). Translin forms a tetramer in the asymmetric unit. Although the monomer structure is almost the same as the crystal structure of murine translin in space group P2(1)2(1)2, the relative positions of the tetramers differ between the human and murine translins. This suggests that the multimerization of translin is flexible; the flexibility may be related to the binding to DNA/RNA.
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===Crystal Structure of human Translin===
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Structure of human translin at 2.2 A resolution.,Sugiura I, Sasaki C, Hasegawa T, Kohno T, Sugio S, Moriyama H, Kasai M, Matsuzaki T Acta Crystallogr D Biol Crystallogr. 2004 Apr;60(Pt 4):674-9. Epub 2004, Mar 23. PMID:15039555<ref>PMID:15039555</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_15039555}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1j1j" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 15039555 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_15039555}}
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__TOC__
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</StructureSection>
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==About this Structure==
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1J1J is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1J1J OCA].
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==Reference==
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<ref group="xtra">PMID:15039555</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Hasegawa, T.]]
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[[Category: Large Structures]]
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[[Category: Kasai, M.]]
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[[Category: Hasegawa T]]
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[[Category: Kohno, T.]]
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[[Category: Kasai M]]
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[[Category: Matsuzaki, T.]]
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[[Category: Kohno T]]
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[[Category: Moriyama, H.]]
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[[Category: Matsuzaki T]]
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[[Category: Sasaki, C.]]
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[[Category: Moriyama H]]
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[[Category: Sugio, S.]]
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[[Category: Sasaki C]]
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[[Category: Sugiura, I.]]
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[[Category: Sugio S]]
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[[Category: Rna binding protein]]
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[[Category: Sugiura I]]
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[[Category: Ssdna binding protein]]
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[[Category: Testis/brain rna binding protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 09:30:50 2009''
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Current revision

Crystal Structure of human Translin

PDB ID 1j1j

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