2f01

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{{Seed}}
 
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[[Image:2f01.png|left|200px]]
 
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==Epi-biotin complex with core streptavidin==
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The line below this paragraph, containing "STRUCTURE_2f01", creates the "Structure Box" on the page.
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<StructureSection load='2f01' size='340' side='right'caption='[[2f01]], [[Resolution|resolution]] 0.85&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2f01]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_avidinii Streptomyces avidinii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F01 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2F01 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 0.85&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BTN:BIOTIN'>BTN</scene>, <scene name='pdbligand=BTQ:EPI-BIOTIN'>BTQ</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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{{STRUCTURE_2f01| PDB=2f01 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2f01 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f01 OCA], [https://pdbe.org/2f01 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2f01 RCSB], [https://www.ebi.ac.uk/pdbsum/2f01 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2f01 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SAV_STRAV SAV_STRAV] The biological function of streptavidin is not known. Forms a strong non-covalent specific complex with biotin (one molecule of biotin per subunit of streptavidin).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f0/2f01_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2f01 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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(+)-Epi-biotin differs from (+)-biotin in the configuration of the chiral center at atom C2. This could lead to a difference in the mode of binding of (+)-epi-biotin to streptavidin, a natural protein receptor for (+)-biotin. Diffraction data were collected to a maximum of 0.85 Angstrom resolution for structural analysis of the complex of streptavidin with a sample of (+)-epi-biotin and refinement was carried out at both 1.0 and 0.85 Angstrom resolution. The structure determination shows a superposition of two ligands in the binding site, (+)-biotin and (+)-epi-biotin. The molecules overlap in the model for the complex except for the position of S1 in the tetrahydrothiophene ring. Differences in the conformation of the ring permits binding of each molecule to streptavidin with little observable difference in the protein structures at this high resolution.
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===Epi-biotin complex with core streptavidin===
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The high-resolution structure of (+)-epi-biotin bound to streptavidin.,Le Trong I, Aubert DG, Thomas NR, Stenkamp RE Acta Crystallogr D Biol Crystallogr. 2006 Jun;62(Pt 6):576-81. Epub 2006, May 12. PMID:16699183<ref>PMID:16699183</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2f01" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_16699183}}, adds the Publication Abstract to the page
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*[[Avidin 3D structures|Avidin 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 16699183 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_16699183}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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2F01 is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Streptomyces_avidinii Streptomyces avidinii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F01 OCA].
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==Reference==
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<ref group="xtra">PMID:16699183</ref><references group="xtra"/>
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[[Category: Streptomyces avidinii]]
[[Category: Streptomyces avidinii]]
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[[Category: Aubert, D G.]]
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[[Category: Aubert DG]]
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[[Category: Stenkamp, R E.]]
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[[Category: Le Trong I]]
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[[Category: Thomas, N R.]]
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[[Category: Stenkamp RE]]
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[[Category: Trong, I Le.]]
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[[Category: Thomas NR]]
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[[Category: Biotin]]
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[[Category: Protein/ligand interaction]]
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[[Category: Streptavidin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 09:38:35 2009''
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Current revision

Epi-biotin complex with core streptavidin

PDB ID 2f01

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