3bm9

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (09:29, 21 February 2024) (edit) (undo)
 
(8 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:3bm9.png|left|200px]]
 
-
<!--
+
==Discovery of Benzisoxazoles as Potent Inhibitors of Chaperone Hsp90==
-
The line below this paragraph, containing "STRUCTURE_3bm9", creates the "Structure Box" on the page.
+
<StructureSection load='3bm9' size='340' side='right'caption='[[3bm9]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[3bm9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BM9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3BM9 FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BXZ:4-BROMO-6-(6-HYDROXY-1,2-BENZISOXAZOL-3-YL)BENZENE-1,3-DIOL'>BXZ</scene></td></tr>
-
{{STRUCTURE_3bm9| PDB=3bm9 | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3bm9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bm9 OCA], [https://pdbe.org/3bm9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3bm9 RCSB], [https://www.ebi.ac.uk/pdbsum/3bm9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3bm9 ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref>
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bm/3bm9_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3bm9 ConSurf].
 +
<div style="clear:both"></div>
-
===Discovery of Benzisoxazoles as Potent Inhibitors of Chaperone Hsp90===
+
==See Also==
-
 
+
*[[Heat Shock Protein structures|Heat Shock Protein structures]]
-
 
+
== References ==
-
<!--
+
<references/>
-
The line below this paragraph, {{ABSTRACT_PUBMED_18197612}}, adds the Publication Abstract to the page
+
__TOC__
-
(as it appears on PubMed at http://www.pubmed.gov), where 18197612 is the PubMed ID number.
+
</StructureSection>
-
-->
+
-
{{ABSTRACT_PUBMED_18197612}}
+
-
 
+
-
==About this Structure==
+
-
3BM9 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BM9 OCA].
+
-
 
+
-
==Reference==
+
-
<ref group="xtra">PMID:18197612</ref><references group="xtra"/>
+
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Arndt, K.]]
+
[[Category: Large Structures]]
-
[[Category: Boschelli, F.]]
+
[[Category: Arndt K]]
-
[[Category: Chopra, R.]]
+
[[Category: Boschelli F]]
-
[[Category: Ellingboe, J.]]
+
[[Category: Chopra R]]
-
[[Category: Golas, J.]]
+
[[Category: Ellingboe J]]
-
[[Category: Gopalsamy, A.]]
+
[[Category: Golas J]]
-
[[Category: Jacob, J.]]
+
[[Category: Gopalsamy A]]
-
[[Category: Johnson, J.]]
+
[[Category: Jacob J]]
-
[[Category: Lee, F.]]
+
[[Category: Johnson J]]
-
[[Category: Nilakantan, R.]]
+
[[Category: Lee F]]
-
[[Category: Peterson, R.]]
+
[[Category: Nilakantan R]]
-
[[Category: Shi, M.]]
+
[[Category: Peterson R]]
-
[[Category: Svenson, K.]]
+
[[Category: Shi M]]
-
[[Category: Tam, M S.]]
+
[[Category: Svenson K]]
-
[[Category: Vogan, E M.]]
+
[[Category: Tam MS]]
-
[[Category: Wen, Y.]]
+
[[Category: Vogan EM]]
-
[[Category: Alternative splicing]]
+
[[Category: Wen Y]]
-
[[Category: Atp binding domain]]
+
-
[[Category: Atp-binding]]
+
-
[[Category: Chaperone]]
+
-
[[Category: Cytoplasm]]
+
-
[[Category: Nucleotide-binding]]
+
-
[[Category: Phosphoprotein]]
+
-
[[Category: Stress response]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 09:41:26 2009''
+

Current revision

Discovery of Benzisoxazoles as Potent Inhibitors of Chaperone Hsp90

PDB ID 3bm9

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3bm9"
Personal tools