1jnp
From Proteopedia
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- | {{Seed}} | ||
- | [[Image:1jnp.png|left|200px]] | ||
- | + | ==Crystal Structure of Murine Tcl1 at 2.5 Resolution== | |
- | + | <StructureSection load='1jnp' size='340' side='right'caption='[[1jnp]], [[Resolution|resolution]] 2.50Å' scene=''> | |
- | + | == Structural highlights == | |
- | + | <table><tr><td colspan='2'>[[1jnp]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JNP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JNP FirstGlance]. <br> | |
- | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5Å</td></tr> | |
- | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jnp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jnp OCA], [https://pdbe.org/1jnp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jnp RCSB], [https://www.ebi.ac.uk/pdbsum/1jnp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jnp ProSAT]</span></td></tr> | |
- | + | </table> | |
- | + | == Function == | |
- | + | [https://www.uniprot.org/uniprot/TCL1A_MOUSE TCL1A_MOUSE] Enhances the phosphorylation and activation of AKT1 and AKT2. Enhances cell proliferation, stabilizes mitochondrial membrane potential and promotes cell survival (By similarity). | |
- | + | == Evolutionary Conservation == | |
- | + | [[Image:Consurf_key_small.gif|200px|right]] | |
- | < | + | Check<jmol> |
- | + | <jmolCheckbox> | |
- | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jn/1jnp_consurf.spt"</scriptWhenChecked> | |
- | + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |
- | + | <text>to colour the structure by Evolutionary Conservation</text> | |
- | + | </jmolCheckbox> | |
- | == | + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jnp ConSurf]. |
- | + | <div style="clear:both"></div> | |
- | + | __TOC__ | |
- | == | + | </StructureSection> |
- | < | + | [[Category: Large Structures]] |
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
- | [[Category: Croce | + | [[Category: Croce CM]] |
- | [[Category: DuBois | + | [[Category: DuBois GC]] |
- | [[Category: Harrison | + | [[Category: Harrison RW]] |
- | [[Category: Petock | + | [[Category: Petock JM]] |
- | [[Category: Torshin | + | [[Category: Torshin IY]] |
- | [[Category: Wang | + | [[Category: Wang YF]] |
- | [[Category: Weber | + | [[Category: Weber IT]] |
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Current revision
Crystal Structure of Murine Tcl1 at 2.5 Resolution
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Categories: Large Structures | Mus musculus | Croce CM | DuBois GC | Harrison RW | Petock JM | Torshin IY | Wang YF | Weber IT