1mse

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{{Seed}}
 
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[[Image:1mse.png|left|200px]]
 
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==SOLUTION STRUCTURE OF A SPECIFIC DNA COMPLEX OF THE MYB DNA-BINDING DOMAIN WITH COOPERATIVE RECOGNITION HELICES==
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The line below this paragraph, containing "STRUCTURE_1mse", creates the "Structure Box" on the page.
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<StructureSection load='1mse' size='340' side='right'caption='[[1mse]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1mse]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MSE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MSE FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1mse FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mse OCA], [https://pdbe.org/1mse PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1mse RCSB], [https://www.ebi.ac.uk/pdbsum/1mse PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1mse ProSAT]</span></td></tr>
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{{STRUCTURE_1mse| PDB=1mse | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MYB_MOUSE MYB_MOUSE] Transcriptional activator; DNA-binding protein that specifically recognize the sequence 5'-YAAC[GT]G-3'. Plays an important role in the control of proliferation and differentiation of hematopoietic progenitor cells.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ms/1mse_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1mse ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The DNA-binding region of Myb consists of three imperfect tandem repeats (R1, R2, and R3). We have determined the solution structure of a specific DNA complex of the minimum DNA-binding domain (R2R3) by heteronuclear multidimensional NMR. Both R2 and R3 contain three helices, and the third helix in each is found to be a recognition helix. R2 and R3 are closely packed in the major groove, so that the two recognition helices contact each other directly to bind to the specific base sequence, AACNG cooperatively; this is a significant arrangement of recognition helices. The three key base pairs in this sequence are specifically recognized by Asn-183 (R3), Lys-182 (R3), and Lys-128 (R2). In contrast, R1 has no specific interactions with DNA from our NMR study of the DNA complex of the full DNA-binding domain (R1R2R3).
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===SOLUTION STRUCTURE OF A SPECIFIC DNA COMPLEX OF THE MYB DNA-BINDING DOMAIN WITH COOPERATIVE RECOGNITION HELICES===
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Solution structure of a specific DNA complex of the Myb DNA-binding domain with cooperative recognition helices.,Ogata K, Morikawa S, Nakamura H, Sekikawa A, Inoue T, Kanai H, Sarai A, Ishii S, Nishimura Y Cell. 1994 Nov 18;79(4):639-48. PMID:7954830<ref>PMID:7954830</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 1mse" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_7954830}}, adds the Publication Abstract to the page
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*[[Transcriptional activator 3D structures|Transcriptional activator 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 7954830 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_7954830}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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1MSE is a 3 chains structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MSE OCA].
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==Reference==
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<ref group="xtra">PMID:7954830</ref><references group="xtra"/>
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[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Inoue, T.]]
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[[Category: Inoue T]]
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[[Category: Ishii, S.]]
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[[Category: Ishii S]]
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[[Category: Kanai, H.]]
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[[Category: Kanai H]]
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[[Category: Morikawa, S.]]
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[[Category: Morikawa S]]
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[[Category: Nakamura, H.]]
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[[Category: Nakamura H]]
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[[Category: Nishimura, Y.]]
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[[Category: Nishimura Y]]
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[[Category: Ogata, K.]]
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[[Category: Ogata K]]
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[[Category: Sarai, A.]]
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[[Category: Sarai A]]
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[[Category: Sekikawa, A.]]
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[[Category: Sekikawa A]]
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[[Category: C-myb dna-binding domain]]
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[[Category: Dna]]
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[[Category: Double helix]]
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[[Category: Nmr]]
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[[Category: Protooncogene product]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 10:04:37 2009''
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Current revision

SOLUTION STRUCTURE OF A SPECIFIC DNA COMPLEX OF THE MYB DNA-BINDING DOMAIN WITH COOPERATIVE RECOGNITION HELICES

PDB ID 1mse

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