2rfv

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{{Seed}}
 
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[[Image:2rfv.png|left|200px]]
 
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==High resolution structure of L-methionine gamma-lyase from Citrobacter freundii==
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The line below this paragraph, containing "STRUCTURE_2rfv", creates the "Structure Box" on the page.
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<StructureSection load='2rfv' size='340' side='right'caption='[[2rfv]], [[Resolution|resolution]] 1.35&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2rfv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Citrobacter_freundii Citrobacter freundii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RFV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RFV FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.355&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene>, <scene name='pdbligand=LLP:(2S)-2-AMINO-6-[[3-HYDROXY-2-METHYL-5-(PHOSPHONOOXYMETHYL)PYRIDIN-4-YL]METHYLIDENEAMINO]HEXANOIC+ACID'>LLP</scene></td></tr>
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{{STRUCTURE_2rfv| PDB=2rfv | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rfv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rfv OCA], [https://pdbe.org/2rfv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rfv RCSB], [https://www.ebi.ac.uk/pdbsum/2rfv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rfv ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q84AR1_CITFR Q84AR1_CITFR]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rf/2rfv_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2rfv ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Pyridoxal 5'-phosphate-dependent methionine gamma-lyase (MGL) is involved in the metabolism of sulfur-containing amino acids. The enzyme is a promising target in some anaerobic pathogens and is effective in cancer-cell treatment. The structure of the MGL holoenzyme from Citrobacter freundii has previously been determined at 1.9 A resolution. By modification of the crystallization procedure, the previously determined structure of C. freundii MGL has been improved to 1.35 A resolution with R and R(free) values of 0.152 and 0.177, respectively. This high-resolution structure makes it possible to analyze the interactions between the monomers in detail and to reveal the structurally invariant regions that are responsible for monomer-monomer recognition during the formation of the active enzyme. Details of the mode of cofactor binding and of the flexible regions that may be involved in substrate recognition and binding are also described.
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===High resolution structure of L-methionine gamma-lyase from Citrobacter freundii===
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High-resolution structure of methionine gamma-lyase from Citrobacter freundii.,Nikulin A, Revtovich S, Morozova E, Nevskaya N, Nikonov S, Garber M, Demidkina T Acta Crystallogr D Biol Crystallogr. 2008 Feb;64(Pt 2):211-8. Epub 2008, Jan 16. PMID:18219122<ref>PMID:18219122</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2rfv" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_18219122}}, adds the Publication Abstract to the page
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*[[Methionine gamma-lyase 3D structures|Methionine gamma-lyase 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 18219122 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_18219122}}
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__TOC__
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</StructureSection>
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==About this Structure==
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2RFV is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Citrobacter_freundii Citrobacter freundii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RFV OCA].
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==Reference==
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<ref group="xtra">PMID:18219122</ref><references group="xtra"/>
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[[Category: Citrobacter freundii]]
[[Category: Citrobacter freundii]]
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[[Category: Methionine gamma-lyase]]
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[[Category: Large Structures]]
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[[Category: Demidkina, T V.]]
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[[Category: Demidkina TV]]
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[[Category: Garber, M B.]]
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[[Category: Garber MB]]
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[[Category: Morozova, E A.]]
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[[Category: Morozova EA]]
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[[Category: Nevskaya, N A.]]
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[[Category: Nevskaya NA]]
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[[Category: Nikonov, S V.]]
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[[Category: Nikonov SV]]
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[[Category: Nikulin, A D.]]
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[[Category: Nikulin AD]]
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[[Category: Revtovich, S V.]]
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[[Category: Revtovich SV]]
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[[Category: Lyase]]
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[[Category: Plp-dependent enzyme]]
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[[Category: Pyridoxal-5'-phosphate]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 10:05:13 2009''
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Current revision

High resolution structure of L-methionine gamma-lyase from Citrobacter freundii

PDB ID 2rfv

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