2zmj

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{{Seed}}
 
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[[Image:2zmj.png|left|200px]]
 
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==Crystal Structure of Rat Vitamin D Receptor Bound to Adamantyl Vitamin D Analogs: Structural Basis for Vitamin D Receptor Antagonism and/or Partial Agonism==
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The line below this paragraph, containing "STRUCTURE_2zmj", creates the "Structure Box" on the page.
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<StructureSection load='2zmj' size='340' side='right'caption='[[2zmj]], [[Resolution|resolution]] 2.35&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2zmj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus] and [https://en.wikipedia.org/wiki/Xenopus_tropicalis Xenopus tropicalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZMJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ZMJ FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.35&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MI4:(1R,3R,7E,17BETA)-17-{(1S,2E,5R)-5-HYDROXY-1-METHYL-6-[(3S,5S,7S)-TRICYCLO[3.3.1.1~3,7~]DEC-1-YL]HEX-2-EN-1-YL}-2-METHYLIDENE-9,10-SECOESTRA-5,7-DIENE-1,3-DIOL'>MI4</scene></td></tr>
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{{STRUCTURE_2zmj| PDB=2zmj | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2zmj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zmj OCA], [https://pdbe.org/2zmj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2zmj RCSB], [https://www.ebi.ac.uk/pdbsum/2zmj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2zmj ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/VDR_RAT VDR_RAT] Nuclear hormone receptor. Transcription factor that mediates the action of vitamin D3 by controlling the expression of hormone sensitive genes. Regulates transcription of hormone sensitive genes via its association with the WINAC complex, a chromatin-remodeling complex. Recruited to promoters via its interaction with the WINAC complex subunit BAZ1B/WSTF, which mediates the interaction with acetylated histones, an essential step for VDR-promoter association. Plays a central role in calcium homeostasis.<ref>PMID:17227670</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zm/2zmj_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2zmj ConSurf].
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<div style="clear:both"></div>
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===Crystal Structure of Rat Vitamin D Receptor Bound to Adamantyl Vitamin D Analogs: Structural Basis for Vitamin D Receptor Antagonism and/or Partial Agonism===
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==See Also==
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*[[Sandbox vdr|Sandbox vdr]]
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*[[Vitamin D receptor 3D structures|Vitamin D receptor 3D structures]]
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== References ==
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The line below this paragraph, {{ABSTRACT_PUBMED_18710208}}, adds the Publication Abstract to the page
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<references/>
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(as it appears on PubMed at http://www.pubmed.gov), where 18710208 is the PubMed ID number.
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__TOC__
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-->
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</StructureSection>
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{{ABSTRACT_PUBMED_18710208}}
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[[Category: Large Structures]]
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==About this Structure==
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2ZMJ is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZMJ OCA].
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==Reference==
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<ref group="xtra">PMID:18710208</ref><references group="xtra"/>
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[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
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[[Category: DeLuca, H F.]]
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[[Category: Xenopus tropicalis]]
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[[Category: Igarashi, M.]]
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[[Category: DeLuca HF]]
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[[Category: Ikura, T.]]
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[[Category: Igarashi M]]
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[[Category: Ito, N.]]
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[[Category: Ikura T]]
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[[Category: Makishima, M.]]
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[[Category: Ito N]]
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[[Category: Nakabayashi, M.]]
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[[Category: Makishima M]]
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[[Category: Shimizu, M.]]
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[[Category: Nakabayashi M]]
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[[Category: Tanaka, T.]]
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[[Category: Shimizu M]]
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[[Category: Tokiwa, H.]]
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[[Category: Tanaka T]]
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[[Category: Yamada, S.]]
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[[Category: Tokiwa H]]
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[[Category: Yoshimoto, N.]]
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[[Category: Yamada S]]
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[[Category: Activator]]
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[[Category: Yoshimoto N]]
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[[Category: Dna-binding]]
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[[Category: Metal-binding]]
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[[Category: Nuclear receptor-antagonist complex]]
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[[Category: Nucleus]]
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[[Category: Phosphoprotein]]
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[[Category: Receptor]]
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[[Category: Transcription]]
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[[Category: Transcription regulation]]
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[[Category: Zinc]]
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[[Category: Zinc-finger]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 10:08:36 2009''
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Current revision

Crystal Structure of Rat Vitamin D Receptor Bound to Adamantyl Vitamin D Analogs: Structural Basis for Vitamin D Receptor Antagonism and/or Partial Agonism

PDB ID 2zmj

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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