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2vuw

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{{Seed}}
 
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[[Image:2vuw.png|left|200px]]
 
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==Structure of human haspin kinase domain==
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The line below this paragraph, containing "STRUCTURE_2vuw", creates the "Structure Box" on the page.
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<StructureSection load='2vuw' size='340' side='right'caption='[[2vuw]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2vuw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VUW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VUW FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5ID:(2R,3R,4S,5R)-2-(4-AMINO-5-IODO-7H-PYRROLO[2,3-D]PYRIMIDIN-7-YL)-5-(HYDROXYMETHYL)TETRAHYDROFURAN-3,4-DIOL'>5ID</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>
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{{STRUCTURE_2vuw| PDB=2vuw | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vuw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vuw OCA], [https://pdbe.org/2vuw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vuw RCSB], [https://www.ebi.ac.uk/pdbsum/2vuw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vuw ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/HASP_HUMAN HASP_HUMAN] Serine/threonine-protein kinase that phosphorylates histone H3 at 'Ser-3' (H3T3ph) during mitosis. This positions and activates AURKB and other components of the chromosomal passenger complex (CPC) at centromeres to ensure proper chromatid cohesion, metaphase alignment and normal progression through the cell cycle.<ref>PMID:11228240</ref> <ref>PMID:15681610</ref> <ref>PMID:17084365</ref> <ref>PMID:20705812</ref> <ref>PMID:20929775</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vu/2vuw_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2vuw ConSurf].
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<div style="clear:both"></div>
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===STRUCTURE OF HUMAN HASPIN KINASE DOMAIN===
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==See Also==
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*[[Serine/threonine protein kinase 3D structures|Serine/threonine protein kinase 3D structures]]
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== References ==
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==About this Structure==
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<references/>
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2VUW is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VUW OCA].
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Non-specific serine/threonine protein kinase]]
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[[Category: Large Structures]]
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[[Category: Arrowsmith, C H.]]
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[[Category: Arrowsmith CH]]
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[[Category: Bountra, C.]]
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[[Category: Bountra C]]
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[[Category: Bray, J.]]
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[[Category: Bray J]]
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[[Category: Burgess-Brown, N.]]
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[[Category: Burgess-Brown N]]
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[[Category: Delft, F Von.]]
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[[Category: Edwards AM]]
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[[Category: Edwards, A M.]]
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[[Category: Eswaran J]]
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[[Category: Eswaran, J.]]
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[[Category: Fedorov O]]
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[[Category: Fedorov, O.]]
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[[Category: Filippakopoulos P]]
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[[Category: Filippakopoulos, P.]]
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[[Category: Keates T]]
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[[Category: Keates, T.]]
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[[Category: King O]]
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[[Category: King, O.]]
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[[Category: Knapp S]]
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[[Category: Knapp, S.]]
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[[Category: Murray JW]]
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[[Category: Murray, J W.]]
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[[Category: Picaud S]]
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[[Category: Picaud, S.]]
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[[Category: Pike ACW]]
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[[Category: Pike, A C.W.]]
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[[Category: Soundararajan M]]
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[[Category: Soundararajan, M.]]
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[[Category: Wickstroem M]]
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[[Category: Wickstroem, M.]]
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[[Category: Von Delft F]]
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[[Category: Alternative splicing]]
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[[Category: Atp-binding]]
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[[Category: Casp8]]
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[[Category: Cell cycle]]
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[[Category: Chromatin regulator]]
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[[Category: Histone kinase]]
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[[Category: Kinase]]
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[[Category: Magnesium]]
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[[Category: Nucleotide-binding]]
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[[Category: Nucleus]]
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[[Category: Phosphoprotein]]
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[[Category: Polymorphism]]
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[[Category: Serine/threonine kinase]]
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[[Category: Serine/threonine-protein kinase]]
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[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 10:11:10 2009''
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Current revision

Structure of human haspin kinase domain

PDB ID 2vuw

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