2rol

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{{Seed}}
 
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[[Image:2rol.jpg|left|200px]]
 
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<!--
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==Structural Basis of PxxDY motif recognition in SH3 binding==
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The line below this paragraph, containing "STRUCTURE_2rol", creates the "Structure Box" on the page.
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<StructureSection load='2rol' size='340' side='right'caption='[[2rol]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2rol]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ROL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ROL FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rol FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rol OCA], [https://pdbe.org/2rol PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rol RCSB], [https://www.ebi.ac.uk/pdbsum/2rol PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rol ProSAT]</span></td></tr>
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{{STRUCTURE_2rol| PDB=2rol | SCENE= }}
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</table>
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== Function ==
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===Structural Basis of PxxDY motif recognition in SH3 binding===
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[https://www.uniprot.org/uniprot/ES8L1_HUMAN ES8L1_HUMAN] Stimulates guanine exchange activity of SOS1. May play a role in membrane ruffling and remodeling of the actin cytoskeleton.<ref>PMID:14565974</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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The line below this paragraph, {{ABSTRACT_PUBMED_18644376}}, adds the Publication Abstract to the page
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<jmolCheckbox>
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(as it appears on PubMed at http://www.pubmed.gov), where 18644376 is the PubMed ID number.
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ro/2rol_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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{{ABSTRACT_PUBMED_18644376}}
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==About this Structure==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2rol ConSurf].
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2ROL is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ROL OCA].
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<div style="clear:both"></div>
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:18644376</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Aitio, O.]]
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[[Category: Large Structures]]
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[[Category: Hellman, M.]]
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[[Category: Aitio O]]
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[[Category: Kesti, T.]]
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[[Category: Hellman M]]
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[[Category: Kleino, I.]]
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[[Category: Kesti T]]
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[[Category: Paakkonen, K.]]
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[[Category: Kleino I]]
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[[Category: Permi, P.]]
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[[Category: Paakkonen K]]
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[[Category: Saksela, K.]]
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[[Category: Permi P]]
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[[Category: Samuilova, O.]]
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[[Category: Saksela K]]
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[[Category: Tossavainen, H.]]
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[[Category: Samuilova O]]
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[[Category: Alternative splicing]]
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[[Category: Tossavainen H]]
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[[Category: Cd3e]]
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[[Category: Coiled coil]]
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[[Category: Complex structure]]
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[[Category: Cytoplasm]]
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[[Category: Eps8l1]]
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[[Category: Immunoglobulin domain]]
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[[Category: Membrane]]
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[[Category: Nmr]]
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[[Category: Phosphoprotein]]
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[[Category: Receptor]]
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[[Category: Sh3]]
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[[Category: Sh3 domain]]
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[[Category: Splicing/signaling protein complex]]
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[[Category: Transmembrane]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 4 14:30:54 2009''
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Current revision

Structural Basis of PxxDY motif recognition in SH3 binding

PDB ID 2rol

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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