3f8t

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (00:29, 28 December 2023) (edit) (undo)
 
(5 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:3f8t.jpg|left|200px]]
 
-
<!--
+
==Crystal structure analysis of a full-length MCM homolog from Methanopyrus kandleri==
-
The line below this paragraph, containing "STRUCTURE_3f8t", creates the "Structure Box" on the page.
+
<StructureSection load='3f8t' size='340' side='right'caption='[[3f8t]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[3f8t]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Methanopyrus_kandleri_AV19 Methanopyrus kandleri AV19]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F8T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3F8T FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
-
-->
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3f8t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3f8t OCA], [https://pdbe.org/3f8t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3f8t RCSB], [https://www.ebi.ac.uk/pdbsum/3f8t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3f8t ProSAT]</span></td></tr>
-
{{STRUCTURE_3f8t| PDB=3f8t | SCENE= }}
+
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/Q8TWB5_METKA Q8TWB5_METKA]
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f8/3f8t_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3f8t ConSurf].
 +
<div style="clear:both"></div>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
The minichromosome maintenance (MCM) proteins, members of the AAA+ (ATPase associated with diverse cellular activities) superfamily, are believed to constitute the replicative helicase in eukaryotic and archaeal species. Here, we present the 1.9 A resolution crystal structure of a monomeric MCM homolog from Methanopyrus kandleri, the first crystallographic structure of a full-length MCM. We also present an 18 A cryo-electron microscopy reconstruction of the hexameric MCM from Methanothermobacter thermautotrophicus, and fit the atomic resolution crystal structure into the reconstruction in order to generate an atomic model for the oligomeric assembly. These structural data reveal a distinct active site topology consisting of a unique arrangement of critical determinants. The structures also provide a molecular framework for understanding the functional contributions of trans-acting elements that facilitate intersubunit crosstalk in response to DNA binding and ATP hydrolysis.
-
===Crystal structure analysis of a full-length MCM homolog from Methanopyrus kandleri===
+
Insights into the architecture of the replicative helicase from the structure of an archaeal MCM homolog.,Bae B, Chen YH, Costa A, Onesti S, Brunzelle JS, Lin Y, Cann IK, Nair SK Structure. 2009 Feb 13;17(2):211-22. PMID:19217392<ref>PMID:19217392</ref>
-
 
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-
<!--
+
</div>
-
The line below this paragraph, {{ABSTRACT_PUBMED_19217392}}, adds the Publication Abstract to the page
+
<div class="pdbe-citations 3f8t" style="background-color:#fffaf0;"></div>
-
(as it appears on PubMed at http://www.pubmed.gov), where 19217392 is the PubMed ID number.
+
== References ==
-
-->
+
<references/>
-
{{ABSTRACT_PUBMED_19217392}}
+
__TOC__
-
 
+
</StructureSection>
-
==About this Structure==
+
[[Category: Large Structures]]
-
3F8T is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Methanopyrus_kandleri_av19 Methanopyrus kandleri av19]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F8T OCA].
+
[[Category: Methanopyrus kandleri AV19]]
-
 
+
[[Category: Bae B]]
-
==Reference==
+
[[Category: Nair SK]]
-
<ref group="xtra">PMID:19217392</ref><references group="xtra"/>
+
-
[[Category: Methanopyrus kandleri av19]]
+
-
[[Category: Bae, B.]]
+
-
[[Category: Nair, S K.]]
+
-
[[Category: Atp-binding]]
+
-
[[Category: Dna replication]]
+
-
[[Category: Dna-binding]]
+
-
[[Category: Helicase]]
+
-
[[Category: Hydrolase]]
+
-
[[Category: Mcm]]
+
-
[[Category: Mcm homolog]]
+
-
[[Category: Nucleotide-binding]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 4 14:52:05 2009''
+

Current revision

Crystal structure analysis of a full-length MCM homolog from Methanopyrus kandleri

PDB ID 3f8t

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3f8t"
Personal tools