3g2g

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{{Seed}}
 
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[[Image:3g2g.jpg|left|200px]]
 
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==S437Y Mutant of human muscle pyruvate kinase, isoform M2==
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The line below this paragraph, containing "STRUCTURE_3g2g", creates the "Structure Box" on the page.
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<StructureSection load='3g2g' size='340' side='right'caption='[[3g2g]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3g2g]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G2G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3G2G FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
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{{STRUCTURE_3g2g| PDB=3g2g | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3g2g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3g2g OCA], [https://pdbe.org/3g2g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3g2g RCSB], [https://www.ebi.ac.uk/pdbsum/3g2g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3g2g ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/KPYM_HUMAN KPYM_HUMAN] Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. Stimulates POU5F1-mediated transcriptional activation. Plays a general role in caspase independent cell death of tumor cells. The ratio betwween the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production. The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival.<ref>PMID:17308100</ref> <ref>PMID:18191611</ref> <ref>PMID:21620138</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g2/3g2g_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3g2g ConSurf].
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<div style="clear:both"></div>
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===S437Y Mutant of human muscle pyruvate kinase, isoform M2===
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==See Also==
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*[[Pyruvate kinase 3D structures|Pyruvate kinase 3D structures]]
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== References ==
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==About this Structure==
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<references/>
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3G2G is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G2G OCA].
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Pyruvate kinase]]
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[[Category: Large Structures]]
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[[Category: Allali-Hassani, A.]]
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[[Category: Allali-Hassani A]]
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[[Category: Arrowsmith, C H.]]
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[[Category: Arrowsmith CH]]
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[[Category: Bochkarev, A.]]
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[[Category: Bochkarev A]]
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[[Category: Bountra, c.]]
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[[Category: Bountra c]]
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[[Category: Dimov, S.]]
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[[Category: Dimov S]]
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[[Category: Edwards, A M.]]
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[[Category: Edwards AM]]
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[[Category: Hong, B.]]
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[[Category: Hong B]]
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[[Category: MacKenzie, F.]]
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[[Category: MacKenzie F]]
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[[Category: Park, H.]]
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[[Category: Park H]]
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[[Category: SGC, Structural Genomics Consortium.]]
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[[Category: Tempel W]]
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[[Category: Tempel, W.]]
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[[Category: Vedadi M]]
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[[Category: Vedadi, M.]]
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[[Category: Weigelt J]]
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[[Category: Weigelt, J.]]
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[[Category: Acetylation]]
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[[Category: Allosteric enzyme]]
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[[Category: Alternative splicing]]
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[[Category: Glycolysis]]
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[[Category: Kinase]]
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[[Category: Magnesium]]
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[[Category: Metal-binding]]
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[[Category: Mutation]]
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[[Category: Phosphoprotein]]
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[[Category: Polymorphism]]
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[[Category: Pyruvate]]
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[[Category: Single nucleotide polymorphism]]
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[[Category: Snp]]
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[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 4 14:58:42 2009''
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Current revision

S437Y Mutant of human muscle pyruvate kinase, isoform M2

PDB ID 3g2g

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